[HTML][HTML] Inhibiting TRK proteins in clinical cancer therapy
AM Lange, HW Lo - Cancers, 2018 - mdpi.com
Gene rearrangements resulting in the aberrant activity of tyrosine kinases have been identified
as drivers of oncogenesis in a variety of cancers. The tropomyosin receptor kinase (TRK) …
as drivers of oncogenesis in a variety of cancers. The tropomyosin receptor kinase (TRK) …
Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast …
…, T Rimkus, A Anderson, A Harrison, AM Lange… - Oncogene, 2018 - nature.com
Signal transducer and activator of transcription 3 (STAT3), glioma oncogene homolog 1 (GLI1),
and truncated GLI1 (tGLI1) are oncogenic transcription factors playing important roles in …
and truncated GLI1 (tGLI1) are oncogenic transcription factors playing important roles in …
Potentiation of sulfonylurea action by an EPAC-selective cAMP analog in INS-1 cells: comparison of tolbutamide and gliclazide and a potential role for EPAC …
…, EPS Pratt, IM Soderling, ML Guerra, AM Lange… - Molecular …, 2013 - ASPET
Tolbutamide and gliclazide block the K ATP channel K ir 6.2/Sur1, causing membrane
depolarization and stimulating insulin secretion in pancreatic beta cells. We examined the ability …
depolarization and stimulating insulin secretion in pancreatic beta cells. We examined the ability …
Uncoupling of Cav1.2 From Ca2+-Induced Ca2+ Release and SK Channel Regulation in Pancreatic β-Cells
…, ML Guerra, AE Salyer, AM Lange… - Molecular …, 2014 - academic.oup.com
We investigated the role of Ca v 1.2 in pancreatic β-cell function by expressing a Ca v 1.2 II-III
loop/green fluorescent protein fusion in INS-1 cells (Ca v 1.2/II-III cells) to disrupt channel-…
loop/green fluorescent protein fusion in INS-1 cells (Ca v 1.2/II-III cells) to disrupt channel-…
Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data
…, JR O'Connell, LR Yanek, M de Andrade, MA Allison… - Nature …, 2022 - nature.com
Analyses of data from genome-wide association studies on unrelated individuals have shown
that, for human traits and diseases, approximately one-third to two-thirds of heritability is …
that, for human traits and diseases, approximately one-third to two-thirds of heritability is …
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
…, LA Lange, MCY Ng, AA Adeyemo, MA Allison… - Nature …, 2013 - nature.com
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass
index (BMI), predominantly in populations of European ancestry. We conducted a meta-…
index (BMI), predominantly in populations of European ancestry. We conducted a meta-…
[HTML][HTML] Genome-wide association of body fat distribution in African ancestry populations suggests new loci
…, DM Becker, LF Bielak, Y Liu, MA Allison… - PLoS …, 2013 - journals.plos.org
Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker
of body fat distribution. Although obesity disproportionately affects minority populations, few …
of body fat distribution. Although obesity disproportionately affects minority populations, few …
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation
…, H Völzke, H Wallaschofski, JG Wilson, M Allison… - Nature …, 2017 - nature.com
Variation in body fat distribution contributes to the metabolic sequelae of obesity. The genetic
determinants of body fat distribution are poorly understood. The goal of this study was to …
determinants of body fat distribution are poorly understood. The goal of this study was to …
[HTML][HTML] Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African …
…, JA Smith, W Zheng, MA Allison… - PLoS …, 2017 - journals.plos.org
Genome-wide association studies (GWAS) have identified >300 loci associated with measures
of adiposity including body mass index (BMI) and waist-to-hip ratio (adjusted for BMI, …
of adiposity including body mass index (BMI) and waist-to-hip ratio (adjusted for BMI, …
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
…, S Sivapalaratnam, G Abecasis, DS Alam, M Allison… - Nature …, 2019 - nature.com
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We
analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for …
analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for …