Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
…, T Jacks, DE Housman, CJ Koch, SW Lowe, AJ Giaccia - nature, 1996 - nature.com
APOPTOSIS is a genetically encoded programme of cell death that can be activated under
physiological conditions 1,2 and may be an important safeguard against tumour development …
physiological conditions 1,2 and may be an important safeguard against tumour development …
[BOOK][B] Radiobiology for the Radiologist
EJ Hall, AJ Giaccia - 2006 - redjournal.org
… Amato Giaccia. As one who teaches from this text, I found the fifth edition to be a clear effort
to … Giaccia has published on the role of hypoxia in promoting cancer aggressiveness and …
to … Giaccia has published on the role of hypoxia in promoting cancer aggressiveness and …
Lysyl oxidase is essential for hypoxia-induced metastasis
Metastasis is a multistep process responsible for most cancer deaths, and it can be influenced
by both the immediate microenvironment (cell–cell or cell–matrix interactions) and the …
by both the immediate microenvironment (cell–cell or cell–matrix interactions) and the …
[PDF][PDF] Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
Tumor cell metastasis is facilitated by "premetastatic niches" formed in destination organs
by invading bone marrow-derived cells (BMDCs). Lysyl oxidase (LOX) is critical for …
by invading bone marrow-derived cells (BMDCs). Lysyl oxidase (LOX) is critical for …
The unique physiology of solid tumors: opportunities (and problems) for cancer therapy
JM Brown, AJ Giaccia - Cancer research, 1998 - AACR
The physiology of solid tumors differs from that of normal tissues in a number of important
aspects, the majority of which stem from differences between the two vasculatures. Compared …
aspects, the majority of which stem from differences between the two vasculatures. Compared …
Pre-metastatic niches: organ-specific homes for metastases
It is well established that organs of future metastasis are not passive receivers of circulating
tumour cells, but are instead selectively and actively modified by the primary tumour before …
tumour cells, but are instead selectively and actively modified by the primary tumour before …
The complexity of p53 modulation: emerging patterns from divergent signals
AJ Giaccia, MB Kastan - Genes & development, 1998 - genesdev.cshlp.org
Functional inactivation of p53 by gene mutation and deletion, protein degradation, or viral
oncogene binding renders a mammalian cell susceptible to oncogenic stimuli and …
oncogene binding renders a mammalian cell susceptible to oncogenic stimuli and …
Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin
…, DC Loomis, F Kaper, AJ Giaccia… - … and cellular biology, 2002 - Taylor & Francis
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor containing an
inducibly expressed HIF-1α subunit and a constititutively expressed HIF-1β subunit. Under …
inducibly expressed HIF-1α subunit and a constititutively expressed HIF-1β subunit. Under …
Loss of PTEN facilitates HIF-1-mediated gene expression
…, AB Jefferson, D Stokoe, AJ Giaccia - Genes & …, 2000 - genesdev.cshlp.org
In glioblastoma-derived cell lines, PTEN does not significantly alter apoptotic sensitivity or
cause complete inhibition of DNA synthesis. However, in these cell lines PTEN regulates …
cause complete inhibition of DNA synthesis. However, in these cell lines PTEN regulates …
Hypoxic control of metastasis
EB Rankin, AJ Giaccia - Science, 2016 - science.org
… Rankin EB and Giaccia AJ, The role of hypoxia-inducible factors in tumorigenesis. Cell … Erler
JT, Bennewith KL, Nicolau M., Dornhöfer N., Kong C., Le QT, Chi JT, Jeffrey SS, and Giaccia …
JT, Bennewith KL, Nicolau M., Dornhöfer N., Kong C., Le QT, Chi JT, Jeffrey SS, and Giaccia …