Δ 9 -Tetrahydrocannabinol (Δ 9 -THC), the major psychoactive ingredient in preparations of
Cannabis sativa (marijuana, hashish), elicits central nervous system (CNS) responses, …

Acute stress suppresses pain by activating brain pathways that engage opioid or non-opioid
mechanisms. Here we show that an opioid-independent form of this phenomenon, termed …

The therapeutic potential of cannabinoids has been the topic of extensive investigation
following the discovery of cannabinoid receptors and their endogenous ligands. Cannabinoid …

Nociceptive neuronal circuits are formed during embryonic and postnatal times when painful
stimuli are normally absent or limited. Today, medical procedures for neonates with health …

Peripheral cannabinoid receptors exert a powerful inhibitory control over pain initiation, but
the endocannabinoid signal that normally engages this intrinsic analgesic mechanism is …

Neuropathic pain is a debilitating form of chronic pain resulting from nerve injury, disease
states, or toxic insults. Neuropathic pain is often refractory to conventional pharmacotherapies, …

Chronic pain states are highly prevalent and yet poorly controlled by currently available
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …

Context Neuropathic pain caused by chemotherapy limits dosing and duration of potentially
life-saving anti-cancer treatment and impairs quality of life. Chemotherapeutic neuropathy …

The endocannabinoid system is implicated in a variety of physiological and pathological
conditions (inflammation, immunomodulation, analgesia, cancer and others). The main active …

This narrative review represents an output from the International Association for the Study of
Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based …