We report the draft genome sequence of the model moss Physcomitrella patens and compare
its features with those of flowering plants, from which it is separated by more than 400 …

Δ 9 -Tetrahydrocannabinol (Δ 9 -THC), the major psychoactive ingredient in preparations of
Cannabis sativa (marijuana, hashish), elicits central nervous system (CNS) responses, …

The psychoactive cannabinoids from Cannabis sativa L. and the arachidonic acid-derived
endocannabinoids are nonselective natural ligands for cannabinoid receptor type 1 (CB 1 ) …

Vascular plants appeared ~410 million years ago, then diverged into several lineages of
which only two survive: the euphyllophytes (ferns and seed plants) and the lycophytes. We …

In the post-genome era, the mouse will have a major role as a model system for functional
genome analysis. This requires a large number of mutants similar to the collections available …

Cannabinoids have immunomodulatory as well as psychoactive effects. Because the central
cannabinoid receptor (cannabinoid CB 1 receptor) is highly expressed in many neuronal …

In 1964, the psychoactive ingredient of Cannabis sativa, Δ 9 -tetrahydrocannabinol (THC),
was isolated. Nearly 30 years later the endogenous counterparts of THC, collectively termed …

Cannabinoids, including the endogenous ligand arachidonyl ethanolamide (anandamide),
elicit not only neurobehavioral but also cardiovascular effects. Two cannabinoid receptors, …

In this study, four cytotoxicity detection assays and four cytotoxic mechanisms were compared
in one cellular system. Cellular responses and their effects were characterized. The …

Prostaglandin E 2 (PGE 2 ) is a crucial mediator of inflammatory pain sensitization. Here, we
demonstrate that inhibition of a specific glycine receptor subtype (GlyR α3) by PGE 2 -…