Background Peroxisome proliferator-activated receptor gamma (PPARγ) agonists are clinically
used to counteract hyperglycemia. However, so far experienced unwanted side effects, …

Nuclear receptors (NRs) represent attractive targets for the treatment of metabolic syndrome-related
diseases. In addition, natural products are an interesting pool of potential ligands …

The roots of Krameria lappacea are used traditionally against oropharyngeal inflammation.
So far, the astringent and antimicrobial properties of its proanthocyanidin constituents are …

Peroxisome proliferator-activated receptor gamma (PPARγ) agonists are used for the
treatment of type 2 diabetes and metabolic syndrome. However, the currently used PPARγ …

Covering: 1994 to 2020 Retinoic acid receptor-related orphan receptors (RORs) belong to a
subfamily of the nuclear receptor superfamily and possess prominent roles in circadian …

Long-term exposure to ascorbate is known to enhance endothelial nitric oxide synthase (eNOS)
activity by stabilizing the eNOS cofactor tetrahydrobiopterin (BH4). We investigated …

Scope Increased macrophage cholesterol efflux (ChE) is considered to have anti‐atherosclerotic
effect counteracting cardiovascular disease. The principle pungent ingredient of the …

Ethnopharmacological relevance In different countries and areas of the world, traditional
medicine has been and is still used for the treatment of various disorders, including chest pain …

Evodiamine, a bioactive alkaloid from the fruits of the traditional Chinese medicine Evodia
rutaecarpa (Juss.) Benth. (Fructus Evodiae, Wuzhuyu), recently gained attention as a dietary …

Leoligin is a natural lignan found in Edelweiss (Leontopodium nivale ssp. alpinum). The
aim of this study was to examine its influence on cholesterol efflux and to address the …