We have studied the interactions of five indolocarbazoles withN-[methyl- 3 H]scopolamine (NMS)
and unlabeled acetylcholine at M 1 -M 4 muscarinic receptors, using equilibrium and …

The ternary allosteric model predicts the possibility of discovering molecules with novel and
highly subtype-selective modes of action. This approach has been applied to muscarinic …

The affinity and allosteric properties of 22 quaternary derivatives of strychnine and brucine
at the m1−m4 subtypes of muscarinic receptors have been analyzed and compared. The …

Recently we described a murine T-cell hybrid that produces activities that promote the
differentiation of eosinophils (eosinophil differentiation factor) and cause proliferation of the BCL1 …

Proteins and small molecules are capable of regulating the agonist binding and function of
G-protein coupled receptors by multiple allosteric mechanisms. In the case of muscarinic …

Two series of pentacyclic carbazolones, 22 and 23, have been synthesized utilizing a facile
intramolecular Diels−Alder reaction and are allosteric modulators at muscarinic …

Cyclosporine (CS) inhibits the stimulation of both T and B lymphocytes by certain agents,
but not by others. Here we have studied the effects of the drug on the responses of murine B …

We have used radioligand binding studies to determine the affinities of seven
bisindolylmaleimide analogues, six of which are selective inhibitors of protein kinase C, at human …

MATERIALS AND METHODS A non-viruliferous population of X. index kindly supplied by
DJ Raski, University of California in January, 1967, was multiplied on fig and grape-vine in …

Loss of forebrain acetylcholine is an early neurochemical lesion in Alzheimer’s disease (AD).
As muscarinic acetylcholine receptors are involved in memory and cognition, a muscarinic …