Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC)
database containing information on over 15,000 control (noncancer) subjects, the allele …

Susceptibility to lung cancer may in part be attributable to inter-individual variability in metabolic
activation or detoxification of tobacco carcinogens. The glutathione S-transferase M1 (…

Because of important roles of cytochromes P450 in the metabolic activation of many
precarcinogens, extensive research in the past has focused on the relationship between the …

The μ class glutathione S-transferase geneGSTM1 is polymorphic in humans, with approximately
half of the Caucasian population being homozygous deleted for this gene. GSTM1 …

Genetically based differences in metabolism, related to MspI restriction site and Ile-Val
polymorphisms of the cytochrome P450 (CYP) 1A1 gene and the null genotype of glutathione …

Certain human biotransformation enzymes have been implicated in the formation and
scavenging of the ultimate reactive metabolites, the diolepoxides, from polycyclic aromatic …

The major identified risk factor for lung cancer is tobacco smoking. We identified previously
the possible modifying influence of CYP1A1 and GSTM1 polymorphisms on lung cancer risk …

Aromatic DNA adducts in total white blood cells, cytochrome P450 (CYP) class 1A1 and
glutathione transferase (GST1) class mu genotypes and micronuclei in T- and B-lymphocytes …

A novel functional polymorphism in the GSTT1 gene associated with the non-conjugator
phenotype has been identified. Sequencing of GSTT1 cDNA revealed a single nucleotide …

Objectives Airborne exposure to polycyclic aromatic hydrocarbons (PAH) in the potroom of
an aluminum reduction plant was studied in relation to genotoxic or mutagenic effects, and …