α 2 -Adrenergic receptors (ARs) play a key role in regulating neurotransmitter release in the
central and peripheral sympathetic nervous systems. To date, three subtypes of α 2 -ARs …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease, …

Myostatin is a negative regulator of skeletal muscle size, previously shown to inhibit muscle
cell differentiation. Myostatin requires both Smad2 and Smad3 downstream of the activin …

The proportion of the population over the age of 65 is growing the most rapidly due to the
longevity revolution. Frailty is prevalent in this age group and strongly associated with disability …

Age-related frailty may be due to decreased skeletal muscle regeneration. The role of TGF-β
molecules myostatin and GDF11 in regeneration is unclear. Recent studies showed an age-…

Human life expectancy has increased dramatically in the last century and as a result also
the prevalence of a variety of age-related diseases and syndromes. One such syndrome is …

… Anne-Ulrike Trendelenburg contributed to signaling work and analyses. Didier Laurent
contributed to clinical study design, imaging implementation, and data interpretation. David J. …

Background Skeletal-muscle differentiation is required for the regeneration of myofibers after
injury. The differentiation capacity of satellite cells is impaired in settings of old age, which …

Brown adipose tissue (BAT) is a key tissue for energy expenditure via fat and glucose oxidation
for thermogenesis. In this study, we demonstrate that the myostatin/activin receptor IIB (…

HDAC4, a class IIa histone deacetylase, is upregulated in skeletal muscle in response to
denervation-induced atrophy. When HDAC4 is deleted postnatally, mice are partially protected …