Cancers have dysfunctional redox regulation resulting in reactive oxygen species production,
damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to …

The onset of inflammation is associated with reactive oxygen species and oxidative damage
to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine …

Extensive efforts have been made to analyze and understand the disappointing trend of
decreasing annual drug approval, particularly when it comes to first-in-class drugs, and this …

A fast and convenient synthetic route towards spiro-oxindole dihydroquinazolinones as
novel and drug-like insulin-regulated aminopeptidase (IRAP) inhibitors is reported. The …

Angiotensin IV (Ang IV) and related peptide analogs, as well as nonpeptide inhibitors of
insulin-regulated aminopeptidase (IRAP), have previously been shown to enhance memory and …

The dCTPase pyrophosphatase 1 (dCTPase) regulates the intracellular nucleotide pool
through hydrolytic degradation of canonical and noncanonical nucleotide triphosphates (dNTPs)…

Glioma-initiating cells (GIC) are considered the underlying cause of recurrences of
aggressive glioblastomas, replenishing the tumor population and undermining the efficacy of …

The zinc metallopeptidase insulin regulated aminopeptidase (IRAP), which is highly expressed
in the hippocampus and other brain regions associated with cognitive function, has been …

Due to a polar or even charged binding interface, DNA-binding proteins are considered
extraordinarily difficult targets for development of small-molecule ligands and only a handful of …

The inhibition of insulin‐regulated aminopeptidase (IRAP, EC 3.4.11.3) by angiotenesin IV
is known to improve memory and learning in rats. Screening 10 500 low‐molecular‐weight …