User profiles for Antonios Kolocouris
Antonios KolocourisProfessor of Medicinal and Organic Chemistry Verified email at pharm.uoa.gr Cited by 3902 |
[HTML][HTML] Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers
An essential protein of the SARS-CoV-2 virus, the envelope protein E, forms a homopentameric
cation channel that is important for virus pathogenicity. Here we report a 2.1-Å structure …
cation channel that is important for virus pathogenicity. Here we report a 2.1-Å structure …
Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L
The main protease (M pro ) of SARS-CoV-2 is a key antiviral drug target. While most M pro
inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently found that …
inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently found that …
Ebselen, disulfiram, carmofur, PX-12, tideglusib, and shikonin are nonspecific promiscuous SARS-CoV-2 main protease inhibitors
…, PI Lagarias, MT Marty, A Kolocouris… - ACS pharmacology & …, 2020 - ACS Publications
Among the drug targets being investigated for SARS-CoV-2, the viral main protease (M pro )
is one of the most extensively studied. M pro is a cysteine protease that hydrolyzes the viral …
is one of the most extensively studied. M pro is a cysteine protease that hydrolyzes the viral …
Membrane protein structure, function, and dynamics: a perspective from experiments and theory
Membrane proteins mediate processes that are fundamental for the flourishing of biological
cells. Membrane-embedded transporters move ions and larger solutes across membranes; …
cells. Membrane-embedded transporters move ions and larger solutes across membranes; …
Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and a FlipGFP-based reporter assay
The papain-like protease (PL pro ) of SARS-CoV-2 is a validated antiviral drug target.
Through a fluorescence resonance energy transfer-based high-throughput screening and …
Through a fluorescence resonance energy transfer-based high-throughput screening and …
Synthesis and antiviral activity evaluation of some new aminoadamantane derivatives. 2
N Kolocouris, A Kolocouris, GB Foscolos… - Journal of medicinal …, 1996 - ACS Publications
The synthesis of some new aminoadamantane derivatives is described. The new compounds
were evaluated against a wide range of viruses [influenza A H1N1, influenza A H2N2, …
were evaluated against a wide range of viruses [influenza A H1N1, influenza A H2N2, …
Spiro [pyrrolidine-2, 2′-adamantanes]: synthesis, anti-influenza virus activity and conformational properties
I Stylianakis, A Kolocouris, N Kolocouris, G Fytas… - Bioorganic & medicinal …, 2003 - Elsevier
Synthetic spiro[pyrrolidine-2,2′-adamantanes] 2, 3, 11, 15, 12, 16, 18, 20 were evaluated in
vitro and found to be active anti-influenza virus A compounds; the effect of the position of C-…
vitro and found to be active anti-influenza virus A compounds; the effect of the position of C-…
Synthesis and antiviral activity evaluation of some aminoadamantane derivatives
N Kolocouris, GB Foscolos, A Kolocouris… - Journal of medicinal …, 1994 - ACS Publications
The synthesis of some spiro [cyclopropane-1, 2'-adamantan]-2-amines and methanamines
and some spiro [pyrrolidine-2, 2'-adamantanes] isdescribed. The title compounds were …
and some spiro [pyrrolidine-2, 2'-adamantanes] isdescribed. The title compounds were …
An effort to understand the molecular basis of hypertension through the study of conformational analysis of losartan and sarmesin using a combination of nuclear …
T Mavromoustakos, A Kolocouris… - Journal of medicinal …, 1999 - ACS Publications
Losartan is the first recently approved drug against hypertension disease that competes with
the biological action of angiotensin II (AII) at the AT1 receptor. Its design was based on the …
the biological action of angiotensin II (AII) at the AT1 receptor. Its design was based on the …
[HTML][HTML] Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro
The dire need for COVID-19 treatments has inspired strategies of repurposing approved
drugs. Amantadine has been suggested as a candidate, and cellular as well as clinical studies …
drugs. Amantadine has been suggested as a candidate, and cellular as well as clinical studies …