Cellular eukaryotic mRNAs (except organellar) contain at the 5′ terminus the structure m7(5′)Gppp(5′)N
(where N is any nucleotide), termed cap. Cap recognition by eukaryotic …

The double-stranded RNA-dependent protein kinase (dsRNA-PK) is thought to be a key
mediator of the antiviral and antiproliferative effects of interferons (IFNs). Studies examining the …

We have examined the effects of human papilloma virus (HPV) E6 proteins on interferon (IFN)
signaling. Here we show that expression of themalignant'HPV-18 E6 in human HT1080 …

The tumor suppressor p53, a sensor of multiple forms of cellular stress, is regulated by post-translational
mechanisms to induce cell-cycle arrest, senescence, or apoptosis. We …

The interferon-inducible, double-stranded RNA-dependent protein kinase PKR has been
implicated in anti-viral, anti-tumor, and apoptotic responses. Others have attempted to examine …

Regeneration of adult tissues depends on somatic stem cells that remain quiescent yet are
primed to enter a differentiation program. The molecular pathways that prevent activation of …

Transport of the essential amino acids arginine and lysine is critical for the survival of mammalian
cells. The adaptive response to nutritional stress involves increased translation of the …

The tumor suppressor p53 is a multifunctional protein that plays a critical role in modulating
cellular responses upon DNA damage or other stresses. These functions of p53 are …

The accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) causes
stress to which an unfolded protein response is activated to render cell survival or apoptosis (…

Cells respond to various forms of stress by activating anti-proliferative pathways, which allow
them to correct the damage caused by stress before re-entering proliferation. If the damage, …