Antibody conjugates directed against intercellular adhesion molecule(ICAM-1) or platelet-endothelial
cell adhesion molecule (PECAM-1) have formed the basis for drug delivery …

Aims/hypothesis The pathophysiology of diabetic retinopathy is linked to hyperglycaemia
and its effect on retinal microvascular tissues. The resulting endothelial injury changes the …

Purpose: Long noncoding RNAs (lncRNAs) previously thought to be “dark matter” of the
genome, play key roles in various biological processes. The lncRNA ANRIL is located at a …

Despite possessing limited protein-coding potential, long non-coding RNAs (lncRNAs) have
been implicated in a myriad of pathologic conditions. Most well documented in cancer, one …

Bitter taste stimuli are detected by a diverse family of G protein-coupled receptors (GPCRs)
expressed in gustatory cells. Each bitter taste receptor (TAS2R) responds to an array of …

Chimeric dyads 1a and 1b based on dansyl and naphthalimide units linked through the
polymethylene group were synthesized, and their photophysical and interactions with various …

Niemann–Pick C1-like protein (NPC1L1) mediates the absorption of dietary cholesterol in
the proximal region of the intestine, a process that is blocked by cholesterol absorption …

Construction productivity is of interest to researchers and practitioners because of its impact
on the performance of construction projects. Despite various studies to identify factors …

Stress‐inducible phosphoprotein 1 (STI1) is part of the chaperone machinery, but it also
functions as an extracellular ligand for the prion protein. However, the physiological relevance …

10.7554/eLife.48625.001 NORAD is a conserved long noncoding RNA (lncRNA) that is
required for genome stability in mammals. NORAD acts as a negative regulator of PUMILIO (PUM…