Epilepsy is one of the more prevalent neurologic disorders in the world, affecting approximately
50 million people of different ages and backgrounds. Epileptic seizures propagating …

Epilepsy, one of the most common neurological disorders worldwide, is characterized by
recurrent seizures and subsequent brain damage. Despite strong evidence supporting a …

Introduction：A robust neuroinflammatory response is a prevalent feature of multiple
neurological disorders, including epilepsy and acute status epilepticus. One component of this …

With interest waning in the use of cyclooxygenase-2 (COX-2) inhibitors for inflammatory
disease, prostaglandin receptors provide alternative targets for the treatment of COX-2–…

G protein-coupled inward rectifier K + (GIRK) channels regulate cellular excitability and
neurotransmission. The GIRK channels are activated by a number of inhibitory neurotransmitters …

Activation of the Gαs-coupled EP2 receptor for prostaglandin E2 (PGE 2 ) promotes cell
survival in several models of tissue damage. To advance understanding of EP2 functions, we …

Exposure to high levels of organophosphorus compounds (OP) can induce status epilepticus
(SE) in humans and rodents via acute cholinergic toxicity, leading to neurodegeneration …

Survivors of exposure to an organophosphorus nerve agent may develop a number of
complications including long-term cognitive deficits (Miyaki et al., 2005; Nishiwaki et al., 2001). …

ATP-sensitive K + (K ATP ) channels are activated by several vasodilating hormones and
neurotransmitters through the PKA pathway. Here, we show that phosphorylation at Ser1387 of …

This review describes an adult rat model of status epilepticus (SE) induced by diisopropyl
fluorophosphate (DFP), and the beneficial outcomes of transient inhibition of the prostaglandin-…