Cyclooxygenase‐2 in epilepsy
Epilepsy is one of the more prevalent neurologic disorders in the world, affecting approximately
50 million people of different ages and backgrounds. Epileptic seizures propagating …
50 million people of different ages and backgrounds. Epileptic seizures propagating …
[HTML][HTML] Impact of stress on epilepsy: focus on neuroinflammation—a mini review
C Espinosa-Garcia, H Zeleke, A Rojas - International journal of molecular …, 2021 - mdpi.com
Epilepsy, one of the most common neurological disorders worldwide, is characterized by
recurrent seizures and subsequent brain damage. Despite strong evidence supporting a …
recurrent seizures and subsequent brain damage. Despite strong evidence supporting a …
The COX-2/prostanoid signaling cascades in seizure disorders
Introduction:A robust neuroinflammatory response is a prevalent feature of multiple
neurological disorders, including epilepsy and acute status epilepticus. One component of this …
neurological disorders, including epilepsy and acute status epilepticus. One component of this …
Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2
…, G Serrano, M Qui, I Speigel, A Rojas… - Proceedings of the …, 2012 - National Acad Sciences
With interest waning in the use of cyclooxygenase-2 (COX-2) inhibitors for inflammatory
disease, prostaglandin receptors provide alternative targets for the treatment of COX-2–…
disease, prostaglandin receptors provide alternative targets for the treatment of COX-2–…
Molecular basis for the inhibition of G protein-coupled inward rectifier K+ channels by protein kinase C
…, X Wang, F Chen, R Wang, A Rojas… - Proceedings of the …, 2004 - National Acad Sciences
G protein-coupled inward rectifier K + (GIRK) channels regulate cellular excitability and
neurotransmission. The GIRK channels are activated by a number of inhibitory neurotransmitters …
neurotransmission. The GIRK channels are activated by a number of inhibitory neurotransmitters …
Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor
…, Y Du, P Thepchatri, A Rojas… - Proceedings of the …, 2010 - National Acad Sciences
Activation of the Gαs-coupled EP2 receptor for prostaglandin E2 (PGE 2 ) promotes cell
survival in several models of tissue damage. To advance understanding of EP2 functions, we …
survival in several models of tissue damage. To advance understanding of EP2 functions, we …
Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus
A Rojas, T Ganesh, N Lelutiu, P Gueorguieva… - …, 2015 - Elsevier
Exposure to high levels of organophosphorus compounds (OP) can induce status epilepticus
(SE) in humans and rodents via acute cholinergic toxicity, leading to neurodegeneration …
(SE) in humans and rodents via acute cholinergic toxicity, leading to neurodegeneration …
Inhibition of the prostaglandin E2 receptor EP2 prevents status epilepticus-induced deficits in the novel object recognition task in rats
A Rojas, T Ganesh, Z Manji, T O'neill, R Dingledine - Neuropharmacology, 2016 - Elsevier
Survivors of exposure to an organophosphorus nerve agent may develop a number of
complications including long-term cognitive deficits (Miyaki et al., 2005; Nishiwaki et al., 2001). …
complications including long-term cognitive deficits (Miyaki et al., 2005; Nishiwaki et al., 2001). …
PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by beta-adrenergic receptors
…, W Shi, Y Yang, X Zhang, A Rojas… - American Journal …, 2007 - journals.physiology.org
ATP-sensitive K + (K ATP ) channels are activated by several vasodilating hormones and
neurotransmitters through the PKA pathway. Here, we show that phosphorylation at Ser1387 of …
neurotransmitters through the PKA pathway. Here, we show that phosphorylation at Ser1387 of …
[HTML][HTML] A rat model of organophosphate-induced status epilepticus and the beneficial effects of EP2 receptor inhibition
A Rojas, T Ganesh, W Wang, J Wang… - Neurobiology of …, 2020 - Elsevier
This review describes an adult rat model of status epilepticus (SE) induced by diisopropyl
fluorophosphate (DFP), and the beneficial outcomes of transient inhibition of the prostaglandin-…
fluorophosphate (DFP), and the beneficial outcomes of transient inhibition of the prostaglandin-…