Poor chemosensitivity and the development of chemoresistance remain major obstacles to
successful chemotherapy of malignant gliomas. GRP78 is a key regulator of the unfolded …

The endoplasmic reticulum (ER) is a multifunctional organelle required for lipid biosynthesis,
calcium storage, and protein folding and processing. A number of physiological and …

The anticancer potency of green tea and its individual components is being intensely
investigated, and some cancer patients already self-medicate with this “miracle herb” in hopes of …

The endoplasmic reticulum (ER) stress response constitutes a cellular process that can be
triggered by a great variety of conditions that cause imbalances in intracellular homeostasis …

The serine/threonine protein phosphatase 2A (PP2A) appears to be critically involved in
cellular growth control and potentially in the development of cancer. A few studies indicated that …

OBJECT Chloroquine (CQ) is a quinoline-based drug widely used for the prevention and
treatment of malaria. More recent studies have provided evidence that this drug may also …

Object In a recent clinical trial, patients with newly diagnosed glioblastoma multiforme
benefited from chloroquine (CQ) in combination with conventional therapy (resection, …

Overexpression of p53 causes G2 arrest, attributable in part to the loss of CDC2 activity.
Transcription of cdc2 andcyclin B1, determined using reporter constructs driven by the two …

The tumor vasculature is essential for tumor growth and survival and is a key target for
anticancer therapy. Glioblastoma multiforme, the most malignant form of brain tumor, is highly …

HIV type 1 (HIV-1) protease inhibitors (PI) have been shown to have anticancer activity in
non–HIV-associated human cancer cells. The underlying mechanism of this effect is unclear. …