Rationale Human embryonic and induced pluripotent stem cells (hESCs/hiPSCs) are promising
cell sources for cardiac regenerative medicine. To realize hESC/hiPSC-based cardiac …

∆1-Tetrahydrocannabinolic acid (THCA) synthase catalyzes the oxidative cyclization of
cannabigerolic acid (CBGA) into THCA, the precursor of the primary psychoactive agent ∆1-…

METHODS The abductor muscle of the dactyl in the 1st or 2nd walking leg of the crayfish (Cambarus
clarkii) was used. The adductor of the dactyl was removed and the leg was placed …

Isx (intestine specific homeobox) is an intestine-specific transcription factor. To elucidate its
physiological function, we generated Isx-deficient mice by knocking in the β-galactosidase …

Mitochondrial Ca 2+ is known to regulate diverse cellular functions, for example energy
production and cell death, by modulating mitochondrial dehydrogenases, inducing production of …

Mitochondrial Ca 2+ is known to change dynamically, regulating mitochondrial as well as
cellular functions such as energy metabolism and apoptosis. The NCLX gene encodes the …

Introduction Human induced pluripotent stem cells (hiPSCs) offer a unique opportunity for
disease modeling. However, it is not invariably successful to recapitulate the disease …

“Salty taste” sensation is evoked when sodium and chloride ions are present together in the
oral cavity. The presence of an epithelial cation channel that receives Na + has previously …

P-type ATPases pump ions across membranes, generating steep electrochemical gradients
that are essential for the function of all cells. Access to the ion-binding sites within the pumps …

Background— The proliferation of cardiomyocytes is highly restricted after postnatal maturation,
limiting heart regeneration. Elucidation of the regulatory machineries for the proliferation …