The action potential in mammalian central neurons

BP Bean - Nature Reviews Neuroscience, 2007 - nature.com
The action potential of the squid giant axon is formed by just two voltage-dependent conductances
in the cell membrane, yet mammalian central neurons typically express more than a …

Classes of calcium channels in vertebrate cells

BP Bean - Annual review of physiology, 1989 - annualreviews.org
… Second, many rat DRG neurons have sustained current components that are not inhibited
by dihydropyridine blockers (LJ Regan, BP Bean, unpublished results). Most results could be …

Mechanisms of calcium channel modulation by β-adrenergic agents and dihydropyridine calcium agonists

RW Tsien, BP Bean, P Hess, JB Lansman… - Journal of molecular and …, 1986 - Elsevier
Cardiac calcium channel activity is markedly increased by β-adrenergic agents or calcium
agonists such as Bay K 8644. The molecular mechanisms underlying these important …

Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state.

BP Bean - Proceedings of the National Academy of …, 1984 - National Acad Sciences
Block of Ca2+ currents by the dihydropyridine drug nitrendipine was studied in single canine
ventricular cells by using the whole-cell variant of the patch clamp technique. When cells …

Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology.

BP Bean - The Journal of general physiology, 1985 - rupress.org
… A preliminary report of this work has appeared (Bean, 1985). … Bean, BP 1984. Nitrendipine
block of cardiac calcium channels… Bean, BP 1985. Two kinds of calcium channels in atria] cells …

P-type calcium channels blocked by the spider toxin ω-Aga-IVA

IM Mintz, VJ Venema, KM Swiderek, TD Lee, BP Bean… - Nature, 1992 - nature.com
VOLTAGE-DEPENDENT calcium channels mediate calcium entry into neurons, which is
crucial for many processes in the brain including synaptic transmission, dendritic spiking, gene …

Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

JE Huettner, BP Bean - Proceedings of the National …, 1988 - National Acad Sciences
Whole-cell and single-channel recording techniques were used to study the action of the
anticonvulsant drug MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]- cyclohepten-5,10-…

Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence

BP Bean - Nature, 1989 - nature.com
THE voltage-dependent calcium current of many neurons is depressed by transmitters such
as noradrenaline 1-3 , GABA 4-6 , and kappa-opiate agonists 7-12 . This modulation …

P-type calcium channels in rat central and peripheral neurons

IM Mintz, ME Adams, BP Bean - Neuron, 1992 - cell.com
… for block of cardiac and neuronal L-type currents (Bean, 1984; Regan et al., 1991). The current
remaining in the … Bean, BP (1989). Classes of calcium channels in vertebrate cells. Annu. …

Lidocaine block of cardiac sodium channels

BP Bean, CJ Cohen, RW Tsien - The Journal of general physiology, 1983 - ncbi.nlm.nih.gov
Bean's present address is Dept. of Physiology and Biophysics, University of Iowa, Iowa City,
… Some of this work has already been reported in preliminary form (Bean et al., 1981; Bean et …