Polymorphisms in human soluble epoxide hydrolase
BD Przybyla-Zawislak, PK Srivastava… - Molecular …, 2003 - ASPET
Human soluble epoxide hydrolase (hsEH) metabolizes a variety of epoxides to the corresponding
vicinal diols. Arachidonic and linoleic acid epoxides are thought to be endogenous …
vicinal diols. Arachidonic and linoleic acid epoxides are thought to be endogenous …
The Saccharomyces cerevisiae Pet309 protein is embedded in the mitochondrial inner membrane
GM Manthey, BD Przybyla‐Zawislak… - European journal of …, 1998 - Wiley Online Library
The nuclear PET309 gene of Saccharomyces cerevisiae is necessary for expression of the
mitochondrial COX1 gene, which encodes subunit I of cytochrome c oxidase. In a pet309 null …
mitochondrial COX1 gene, which encodes subunit I of cytochrome c oxidase. In a pet309 null …
Identification of rat hippocampal mRNAs altered by the mitochondrial toxicant, 3‐NPA
BD PRZYBYLA‐ZAWISLAK, BT Thorn… - Annals of the New …, 2005 - Wiley Online Library
3‐Nitropropionic acid (3‐NPA) is a model mitochondrial inhibitor that causes selective
neurodegeneration in brain. 3‐NPA‐induced neurodegeneration occurs via a secondary …
neurodegeneration in brain. 3‐NPA‐induced neurodegeneration occurs via a secondary …
The differential JunB responses to inhibition of succinate dehydrogenase in rat hippocampus and liver
BD Przybyla-Zawislak, CS Kim, SF Ali, W Slikker Jr… - Neuroscience …, 2005 - Elsevier
The inhibitor of mitochondrial enzyme succinate dehydrogenase, 3-nitropropionic acid (3-NPA),
induces cellular energy deficit followed by oxidative stress, secondary excitotoxicity and …
induces cellular energy deficit followed by oxidative stress, secondary excitotoxicity and …
Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes
B Przybyla-Zawislak, DM Gadde, K Ducharme… - Genetics, 1999 - academic.oup.com
The eight enzymes of the tricarboxylic acid (TCA) cycle are encoded by at least 15 different
nuclear genes in Saccharomyces cerevisiae. We have constructed a set of yeast strains …
nuclear genes in Saccharomyces cerevisiae. We have constructed a set of yeast strains …
Global transcription analysis of Krebs tricarboxylic acid cycle mutants reveals an alternating pattern of gene expression and effects on hypoxic and oxidative genes
…, CB Epstein, B Przybyla-Zawislak… - Molecular biology of …, 2003 - Am Soc Cell Biol
To understand the many roles of the Krebs tricarboxylic acid (TCA) cycle in cell function, we
used DNA microarrays to examine gene expression in response to TCA cycle dysfunction. …
used DNA microarrays to examine gene expression in response to TCA cycle dysfunction. …
Co-regulation of dopamine D1 receptor and uncoupling protein-2 expression in 3-nitropropionic acid-induced neurotoxicity: neuroprotective role of L-carnitine
…, SF Ali, A Virmani, A Amato, N Salem, BD Przybyla - Neuroscience …, 2006 - Elsevier
This study tested the hypothesis that the expression of uncoupling proteins (UCPs) and
dopamine (DA) system genes is responsive to 3-nitropropionic acid (3-NPA) neurotoxic effects …
dopamine (DA) system genes is responsive to 3-nitropropionic acid (3-NPA) neurotoxic effects …
[HTML][HTML] Soluble epoxide hydrolase dimerization is required for hydrolase activity
JW Nelson, RM Subrahmanyan, SA Summers… - Journal of Biological …, 2013 - ASBMB
Soluble epoxide hydrolase (sEH) plays a key role in the metabolic conversion of the
protective eicosanoid 14,15-epoxyeicosatrienoic acid to 14,15-dihydroxyeicosatrienoic acid. …
protective eicosanoid 14,15-epoxyeicosatrienoic acid to 14,15-dihydroxyeicosatrienoic acid. …
Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury
IP Koerner, R Jacks, AE DeBarber, D Koop… - Journal of …, 2007 - Soc Neuroscience
Single nucleotide polymorphisms (SNPs) in the human EPHX2 gene have recently been
implicated in susceptibility to cardiovascular disease, including stroke. EPHX2 encodes for …
implicated in susceptibility to cardiovascular disease, including stroke. EPHX2 encodes for …
[HTML][HTML] Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation [S]
Epoxy FAs (EpFAs) are important lipid mediators that are mainly metabolized by soluble
epoxide hydrolase (sEH). Thus, sEH inhibition is a promising therapeutic target to treat …
epoxide hydrolase (sEH). Thus, sEH inhibition is a promising therapeutic target to treat …