Voltage-sensitive sodium channels play a key role in action potentials generation in many
excitable membranes. No wonder therefore is it that, in the course of evolution of the living …

1 The objective of this study was to clarify the relationships between loss of mitochondrial
potential and the perturbation of neuronal Ca 2+ homeostasis induced by a toxic glutamate …

1 Exposure of hippocampal neurones to glutamate at toxic levels is associated with a profound
collapse of mitochondrial potential and deregulation of calcium homeostasis. We have …

1 Using whole‐cell patch‐clamp techniques, the mechanisms of NMDA channel blockade by
amino‐adamantane derivatives (AADs) memantine (3,5‐dimethyl‐aminoadamantane, MEM…

Using whole-cell patch-clamp techniques, we studied the interaction of open NMDA channels
with tetraalkylammonium compounds: tetraethylammonium (TEA), tetrapropylammonium (…

The electrical excitability of nerve and muscle is based on the properties of Na÷ and K÷ ion-selective
channels able to open and close in response to changes of membrane potential. …

Neurons acutely isolated from the CA1 region of rat hippocampal slices using the ‘vibrodissociation’
method were voltage-clamped in the whole-cell configuration. The currents through …

Analysis of the mechanisms of propagation of excitation through heterogeneous fibres is of
great interest to the biophysicist and neurophysiologist since the problem" To be or not to be" …

For the first time, simultaneous monitoring of changes in the concentration of cytosolic ATP ([ATP]
c ), pH (pH c ), and intracellular free Ca 2+ concentration ([Ca 2+ ] i ) of the individual …

This paper summarizes the investigations of the mode of action of batrachotoxin on frog
myelinated nerve fibres. Batrachotoxin (10 −7 −10 −5 m) alters a certain fraction of the sodium …