Accuracy and calibration of commercial oligonucleotide and custom cDNA microarrays
…, E Wurmbach, RL Pfeffer, BJ Ebersole… - Nucleic acids …, 2002 - academic.oup.com
We compared the accuracy of microarray measurements obtained with oligonucleotide
arrays (GeneChip, Affymetrix) with a laboratory-developed cDNA array by assaying test RNA …
arrays (GeneChip, Affymetrix) with a laboratory-developed cDNA array by assaying test RNA …
Influenza virus evades innate and adaptive immunity via the NS1 protein
A Fernandez-Sesma, S Marukian, BJ Ebersole… - Journal of …, 2006 - Am Soc Microbiol
Both antibodies and T cells contribute to immunity against influenza virus infection. However,
the generation of strong Th1 immunity is crucial for viral clearance. Interestingly, we found …
the generation of strong Th1 immunity is crucial for viral clearance. Interestingly, we found …
Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex
J González-Maeso, T Yuen, BJ Ebersole… - Journal of …, 2003 - Soc Neuroscience
Most neuropharmacological agents and many drugs of abuse modulate the activity of
heptahelical G-protein-coupled receptors. Although the effects of these ligands result from …
heptahelical G-protein-coupled receptors. Although the effects of these ligands result from …
[HTML][HTML] Mapping the binding site pocket of the serotonin 5-hydroxytryptamine2A receptor: Ser3. 36 (159) provides a second interaction site for the protonated amine of …
N Almaula, BJ Ebersole, D Zhang, H Weinstein… - Journal of Biological …, 1996 - ASBMB
Like other amine neurotransmitters that activate G-protein-coupled receptors, 5-hydroxytryptamine
(5-HT) binds to the 5-HT 2A receptor through the interaction of its cationic primary …
(5-HT) binds to the 5-HT 2A receptor through the interaction of its cationic primary …
[HTML][HTML] Related Contribution of Specific Helix 2 and 7 Residues to Conformational Activation of the Serotonin 5-HT2A Receptor (∗)
SC Sealfon, L Chi, BJ Ebersole, V Rodic… - Journal of Biological …, 1995 - ASBMB
A conserved helix 2 Asp is required for the proper function of many G-protein-coupled receptors.
To reveal the structural basis for the role of this residue, the additive effects of mutations …
To reveal the structural basis for the role of this residue, the additive effects of mutations …
[HTML][HTML] Gonadotropin-releasing hormone receptor-coupled gene network organization* 210
E Wurmbach, T Yuen, BJ Ebersole… - Journal of Biological …, 2001 - ASBMB
An early gene cDNA microarray was developed to study genes that are regulated immediately
following gonadotropin-releasing hormone (GnRH) receptor activation. 956 selected …
following gonadotropin-releasing hormone (GnRH) receptor activation. 956 selected …
[HTML][HTML] Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor: identification of a novel “locked-on” phenotype and double …
C Prioleau, I Visiers, BJ Ebersole, H Weinstein… - Journal of Biological …, 2002 - ASBMB
Studies in many rhodopsin-like G-protein-coupled receptors are providing a general
scheme of the structural processes underlying receptor activation. Microdomains in several …
scheme of the structural processes underlying receptor activation. Microdomains in several …
Contribution of a helix 5 locus to selectivity of hallucinogenic and nonhallucinogenic ligands for the human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C …
N Almaula, BJ Ebersole, JA Ballesteros… - Molecular …, 1996 - ASPET
An important determinant of the neurobehavioral responses induced by a drug is its relative
receptor selectivity. The molecular basis of ligand selectivity of hallucinogenic and …
receptor selectivity. The molecular basis of ligand selectivity of hallucinogenic and …
Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy
BJ Ebersole, I Visiers, H Weinstein, SC Sealfon - Molecular Pharmacology, 2003 - ASPET
Based on experiment and computational simulation, we present a structural explanation for
the differing efficacies of indole agonists at the human serotonin 5-HT2A receptor (5HT2AR). …
the differing efficacies of indole agonists at the human serotonin 5-HT2A receptor (5HT2AR). …
Transcript profiling of immediate early genes reveals a unique role for activating transcription factor 3 in mediating activation of the glycoprotein hormone α-subunit …
J Xie, SP Bliss, TM Nett, BJ Ebersole… - Molecular …, 2005 - academic.oup.com
Recent studies profiling immediate early gene responses to GnRH in the LβT2 gonadotrope
cell model revealed increased expression of numerous genes including activating …
cell model revealed increased expression of numerous genes including activating …