Antidepressants such as Selective Serotonin Reuptake Inhibitors (SSRI) act as indirect
agonists of serotonin (5-HT) receptors. Although these drugs produce a rapid blockade of …

Central dopaminergic and noradrenergic systems play essential roles in controlling several
forebrain functions. Consequently, perturbations of these neurotransmissions may contribute …

5-Hydroxytryptamine 2A receptors (5-HT 2A -Rs) are G-protein coupled receptors. In
agreement with their location in the brain, they have been implicated not only in various central …

Understanding the physiopathology of affective disorders and their treatment relies on the
availability of experimental models that accurately mimic aspects of the disease. Here we …

Worldwide, 100 million people are expected to die this century from the consequences of
nicotine addiction 1 , but nicotine is also known to enhance cognitive performance 2 . …

Most depressed patients don't respond to their first drug treatment, and the reasons for this
treatment resistance remain enigmatic. Human studies implicate a polymorphism in the …

Anatomical studies have established the existence of reciprocal relationships between the
main population of monoamine, serotonin (5-HT), norepinephrine (NE) and dopamine (DA) …

The therapeutic activity of selective serotonin (5-HT) reuptake inhibitors (SSRIs) relies on
long-term adaptation at pre-and post-synaptic levels. The sustained administration of SSRIs …

Identifying the factors contributing to the etiology of anxiety and depression is critical for the
development of more efficacious therapies. Serotonin (5-HT) is intimately linked to both …

Background and Purpose The link between type 2 diabetes mellitus (T2DM) and depression
is bidirectional. However, the possibility that metabolic disorders may elicit anxiogenic‐like/…