Neuroendocrine differentiation in prostatic carcinomas: histogenesis, biology, clinical relevance, and future therapeutical perspectives

B Helpap, J Köllermann, U Oehler - Urologia internationalis, 1999 - karger.com
Since the introduction of immunohistochemistry, there is an increasing interest in
neuroendocrine (NE) differentiation in prostatic carcinomas. Focal NE differentiation in prostatic …

The significance of modified Gleason grading of prostatic carcinoma in biopsy and radical prostatectomy specimens

B Helpap, L Egevad - Virchows Archiv, 2006 - Springer
… 1a and b) were compared by regrading 368 radical prostatectomy specimens and the
available preoperative biopsies, and we estimated the agreement of conventional and modified …

Molecular pathology of non-invasive urothelial carcinomas (part I)

B Helpap, BJ Schmitz-Dräger, PW Hamilton… - Virchows Archiv, 2003 - Springer
An international consultation on the diagnosis of non-invasive urothelial neoplasms was held
in Ancona, Italy in May 2001. Besides histology and problems of classification, one group …

Immunohistochemical analysis of the proliferative activity of neuroendocrine tumors from various organs: Are there indications for a neuroendocrine tumor–carcinoma …

B Helpap, J Köllermann - Virchows Archiv, 2001 - Springer
Small-cell neuroendocrine carcinomas (NECs) of the prostate are believed not to derive from
benign orthotopic NE epithelial cells. Instead, an origin from a putative stem cell is actually …

Undifferentiated carcinoma of the prostate with small cell features: immunohistochemical subtyping and reflections on histogenesis

B Helpap, J Köllermann - Virchows Archiv, 1999 - Springer
To investigate the histogenesis of undifferentiated carcinoma of the prostate with small cell
features we analysed the expression of neuroendocrine (NE) markers, the androgen receptor …

Expression of vascular endothelial growth factor (VEGF) and VEGF receptor Flk-1 in benign, premalignant, and malignant prostate tissue

J Köllermann, B Helpap - American journal of clinical pathology, 2001 - academic.oup.com
Vascular endothelial growth factor (VEGF) is one of the most potent mitogenic, highly specific
tumor angiogenic factors, which acts via binding to 2 specific tyrosine kinase receptors. …

Morphology and therapeutic strategies for neuroendocrine tumors of the genitourinary tract

B Helpap - Cancer, 2002 - Wiley Online Library
Morphology and therapeutic strategies for neuroendocrine tumors of the genitourinary tract -
Helpap - 2002 - Cancer - Wiley Online Library … Burkhard Helpap MD … Burkhard Helpap MD …

[PDF][PDF] Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures.

L Prezeau, J Carrette, B Helpap, K Curry, JP Pin… - Molecular …, 1994 - Citeseer
Several cDNAs coding for metabotropic glutamate receptors (mGIuRl-7) have now been
isolated. mGIuR1 and-5 are positively coupled to phospholipase C, whereas mGIuR2,-3,-4,-6, …

Observations on the number, size and localization of nucleoli in hyperplastic and neoplastic prostatic disease

B Helpap - Histopathology, 1988 - Wiley Online Library
Specimens of prostate obtained for histopathological and cytological examination by urethral
resection and ‘punch’ biopsies showing carcinoma, atypical and typical hyper‐plasia were …

Osteoclast-like giant cell tumour of the pancreas presenting as a pseudocyst-like lesion

U Oehler, M Jürs, G Klöppel, B Helpap - Virchows Archiv, 1997 - Springer
A 57-year-old male patient presented with a cystic lesion in the tail of the pancreas, which
was considered to be a pseudocyst. He was treated by cystojejunostomy but one year later a …