Glycogen synthase kinase (GSK)-3 is a serine/threonine kinase that has been implicated in
several aspects in embryonic development and several growth factor signaling cascades. …

Collapsin response mediator proteins (CRMPs) are a family of neuron-enriched proteins
that regulate neurite outgrowth and growth cone dynamics. Here, we show that Cdk5 …

Neuropilin-1 (NP1), in conjunction with plexins, promotes axon repulsion by binding to
semaphorin 3A (SEMA3A). Although NP1 is expressed in carcinoma cells, its functions have …

Astrocytes are the most prevalent glial cells in the brain. Historically considered as “merely
supporting” neurons, recent research has shown that astrocytes actively participate in a large …

Collapsin-1 belongs to the Semaphorin family of molecules, several members of which have
been implicated in the co-ordination of axon growth and guidance. Collapsin-1 can function …

Distinct changes in glycogen synthase kinase-3 (GSK-3) signalling can regulate neuronal
morphogenesis including the determination and maintenance of axonal identity, and are …

Marking functionally distinct neuronal ensembles with high spatiotemporal resolution is a
key challenge in systems neuroscience. We recently introduced CaMPARI, an engineered …

The expression and function of the 8 distinct catalytic isoforms of PI 3-kinase (PI3K) in the
nervous system are unknown. Whereas most PI3Ks have a broad tissue distribution, the …

Background Germline mutations in the phosphatase PTEN are associated with diverse human
pathologies, including tumour susceptibility, developmental abnormalities and autism, but …

Protein ubiquitination is a core regulatory determinant of neural development. Previous
studies have indicated that the Nedd4-family E3 ubiquitin ligases Nedd4-1 and Nedd4-2 may …