User profiles for B. Pluvinage

Benjamin Pluvinage

University of Victoria
Verified email at uvic.ca
Cited by 1280

Glycan‐metabolizing enzymes in microbe–host interactions: the Streptococcus pneumoniae paradigm

JK Hobbs, B Pluvinage, AB Boraston - FEBS letters, 2018 - Wiley Online Library
Streptococcus pneumoniae is a frequent colonizer of the upper airways; however, it is also
an accomplished pathogen capable of causing life‐threatening diseases. To colonize and …

[HTML][HTML] Molecular basis of an agarose metabolic pathway acquired by a human intestinal symbiont

B Pluvinage, JM Grondin, C Amundsen… - Nature …, 2018 - nature.com
In red algae, the most abundant principal cell wall polysaccharides are mixed galactan
agars, of which agarose is a common component. While bioconversion of agarose is …

Metabolism of a hybrid algal galactan by members of the human gut microbiome

CS Robb, JK Hobbs, B Pluvinage, G Reintjes… - Nature chemical …, 2022 - nature.com
Native porphyran is a hybrid of porphryan and agarose. As a common element of edible
seaweed, this algal galactan is a frequent component of the human diet. Bacterial members of …

[HTML][HTML] Substrate recognition and hydrolysis by a family 50 exo-β-agarase, Aga50D, from the marine bacterium Saccharophagus degradans

B Pluvinage, JH Hehemann, AB Boraston - Journal of Biological Chemistry, 2013 - ASBMB
The bacteria that metabolize agarose use multiple enzymes of complementary specificities
to hydrolyze the glycosidic linkages in agarose, a linear polymer comprising the repeating …

Recognition of protein-linked glycans as a determinant of peptidase activity

I Noach, E Ficko-Blean, B Pluvinage… - Proceedings of the …, 2017 - National Acad Sciences
The vast majority of proteins are posttranslationally altered, with the addition of covalently
linked sugars (glycosylation) being one of the most abundant modifications. However, despite …

[HTML][HTML] Insights into the κ/ι-carrageenan metabolism pathway of some marine Pseudoalteromonas species

AG Hettle, JK Hobbs, B Pluvinage, C Vickers… - Communications …, 2019 - nature.com
Pseudoalteromonas is a globally distributed marine-associated genus that can be found in
a broad range of aquatic environments, including in association with macroalgal surfaces …

[HTML][HTML] Unravelling the Multiple Functions of the Architecturally Intricate Streptococcus pneumoniae β-galactosidase, BgaA

AK Singh, B Pluvinage, MA Higgins, AB Dalia… - PLoS …, 2014 - journals.plos.org
Bacterial cell-surface proteins play integral roles in host-pathogen interactions. These
proteins are often architecturally and functionally sophisticated and yet few studies of such …

The molecular basis of glycogen breakdown and transport in Streptococcus pneumoniae

…, MA Higgins, S Hyrnuik, B Pluvinage… - Molecular …, 2010 - Wiley Online Library
The genome of Streptococcus pneumoniae strains, as typified by the TIGR4 strain, contain
several genes encoding proteins putatively involved in α‐glucan degradation, modification …

Architecturally complex O-glycopeptidases are customized for mucin recognition and hydrolysis

B Pluvinage, E Ficko-Blean, I Noach… - Proceedings of the …, 2021 - National Acad Sciences
A challenge faced by peptidases is the recognition of highly diverse substrates. A feature of
some peptidase families is the capacity to specifically use post-translationally added glycans …

The Glycoprotease CpaA Secreted by Medically Relevant Acinetobacter Species Targets Multiple O-Linked Host Glycoproteins

…, NE Scott, G Di Venanzio, J Lopez, B Pluvinage… - MBio, 2020 - Am Soc Microbiol
Glycans decorate proteins and affect their biological function, including protection against
proteolytic degradation. However, pathogenic, and commensal bacteria have evolved specific …