[HTML][HTML] Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity

…, S Das, J Ramirez, B Poonkuzhali… - Journal of clinical …, 2008 - ncbi.nlm.nih.gov
… We have recently identified four functional polymorphisms in the 5′-regulatory region of
ABCG2 (Poonkuzhali et al, manuscript submitted for publication). The −15994G>A (rs7699188) …

Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation

A Srivastava, B Poonkuzhali, RV Shaji, B George… - Blood, 2004 - ashpublications.org
… Age, serum bilirubin level, ferritin level, aspartate aminotransferase (AST) level, alanine
aminotransferase (ALT) level, hepatitis B or C virus infection, and Lucarelli et al's 21 …

Transporter-mediated protection against thiopurine-induced hematopoietic toxicity

…, H Nakauchi, C Marzolini, RB Kim, B Poonkuzhali… - Cancer research, 2008 - AACR
Thiopurines are effective immunosuppressants and anticancer agents, but intracellular
accumulation of their active metabolites (6-thioguanine nucleotides, 6-TGN) causes dose-limiting …

Clinical predictors of serum clozapine levels in patients with treatment-resistant schizophrenia

AP Rajkumar, B Poonkuzhali, A Kuruvilla… - International clinical …, 2013 - journals.lww.com
Fixed oral doses of clozapine produce up to 45-fold interindividual variability among its
serum levels in patients with treatment-resistant schizophrenia. Although the relationship …

Treatment of children with newly diagnosed acute promyelocytic leukemia with arsenic trioxide: a single center experience

B George, V Mathews, B Poonkuzhali, RV Shaji… - Leukemia, 2004 - nature.com
A total of 11 children (five males and six females) with hypergranular type of acute promyelocytic
leukemia (APML) were treated with intravenous arsenic trioxide (As 2 O 3) between …

Association of breast cancer resistance protein/ABCG2 phenotypes and novel promoter and intron 1 single nucleotide polymorphisms

B Poonkuzhali, J Lamba, S Strom, A Sparreboom… - Drug metabolism and …, 2008 - ASPET
B, snapshot from the ECR browser with alignment of human BCRP with mouse and rat. C,
results from the rVISTA browser with local alignment of mouse and human BCRP. D, Cister …

A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression

…, RG Tirona, G Gervasini, B Poonkuzhali… - Molecular …, 2007 - academic.oup.com
The farnesoid X receptor (FXR or NR1H4) is an important bile-acid-activated, transcriptional
regulator of genes involved in bile acid, lipid, and glucose homeostasis. Accordingly, …

[HTML][HTML] Clinical predictors of response to clozapine in patients with treatment resistant schizophrenia

…, S Bhuvaneshwari, B Poonkuzhali… - Psychopharmacology …, 2011 - ncbi.nlm.nih.gov
Objectives Despite clozapine’s superior clinical efficacy in Treatment Resistant Schizophrenia
(TRS), its adverse effects, need for periodic leukocyte monitoring, cost and variable …

Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with …

AP Rajkumar, B Poonkuzhali, A Kuruvilla… - …, 2012 - Springer
Rationale Pharmacogenetics of schizophrenia has not yet delivered anticipated clinical
dividends. Clinical heterogeneity of schizophrenia contributes to the poor replication of the …

Glutathione S-transferase activity influences busulfan pharmacokinetics in patients with beta thalassemia major undergoing bone marrow transplantation

B Poonkuzhali, M Chandy, A Srivastava… - Drug metabolism and …, 2001 - ASPET
… Patients were randomly assigned to two groups, A and B, conditioned as follows: regimen
A, 16 mg/kg busulfan + 200 mg/kg cyclophosphamide + antithymocyte globulin; regimen B, …