Astrocytes tile the entire CNS. They are vital for neural circuit function, but have traditionally
been viewed as simple, homogenous cells that serve the same essential supportive roles …

Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional
remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was …

P2X receptors are membrane ion channels activated by the binding of extracellular
adenosine triphosphate (ATP). For years their functional significance was consigned to distant …

Astrocytes are a type of glial cell that tile the CNS. They interact with multiple cell types, including
neurons, glial cells and blood vessels, and are involved or implicated in brain disorders…

Huntington's disease (HD) is characterized by striatal medium spiny neuron (MSN) dysfunction,
but the underlying mechanisms remain unclear. We explored roles for astrocytes, in …

Astrocytes are morphologically complex, ubiquitous cells that are viewed as a homogeneous
population tiling the entire central nervous system (CNS). However, this view has been …

Hyperactivity and disturbances of attention are common behavioral disorders whose
underlying cellular and neural circuit causes are not understood. We report the discovery that …

Astrocytes are ubiquitous in the brain and are widely held to be largely identical. However,
this view has not been fully tested, and the possibility that astrocytes are neural circuit …

Astrocytes contribute to the formation and function of synapses and are found throughout
the brain, where they show intracellular store–mediated Ca 2+ signals. Here, using a …

Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are
widely regarded as causal in this failure. Here, using three genetically targeted loss-of-function …