Currently, there is a major effort to map protein–protein interactions on a genome-wide scale.
The utility of the resulting interaction networks will depend on the reliability of the …

Ubiquitin‐protein ligases (E3s) are responsible for target recognition and regulate stability,
localization or function of their substrates. However, the substrates of most E3 enzymes …

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR) gene, which encodes a cAMP-activated anion channel expressed in epithelial cells. …

SCF complexes are multi‐subunit ubiquitin ligases that, in concert with the E1 and E2
ubiquitination enzymes, catalyze the ubiquination of specific target proteins. Only three yeast SCFs …

Ubiquitin conjugation and in particular two distinct HECT ubiquitin ligases, Rsp5p and
Tom1p, have been shown to participate in the regulation of mRNA export in Saccharomyces …

Background Small molecules as shown by VX809 can rescue the mislocalization of F508del-CFTR.
The aim of this study was to identify correctors with a clinical history and their targets …

Ubiquitin-protein ligases (E3s) are implicated in various human disorders and are attractive
targets for therapeutic intervention. Although most cellular proteins are ubiquitinated, …

RECENT studies have shown neuroprotective effects of acetylsalicylic acid (ASA) in cell
cultures and hippocampal slices. The present study demonstrates similar effects in a whole-…

Currently, there is a major effort to map protein-protein interactions on a genome-wide scale.
The utility of the resulting interaction networks will depend on the reliability of the …

Cystic Fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR) gene, which encodes a cAMP-activated anion channel expressed in epithelial cells. …