Preclinical efficacy of iv IT-101, a nanoparticulate conjugate of 20(S)-camptothecin and a
cyclodextrin-based polymer, was investigated in several mouse xenografts. The effects of …

Purpose: Inhibition of the vascular endothelial growth factor (VEGF) axis is the basis of all
currently approved antiangiogenic therapies. In preclinical models, anti-VEGF blocking …

Animal models have contributed significantly to our understanding of the underlying biological
mechanisms of Alzheimer's disease (AD). As a result, over 300 interventions have been …

Modulation of aberrant cell cycle regulation is a potential therapeutic strategy applicable to
a wide range of tumor types. JNJ-7706621 is a novel cell cycle inhibitor that showed potent …

Rationale: There are limited therapeutic options for patients with coronavirus disease (COVID-19)-related
acute respiratory distress syndrome with inflammation-mediated lung injury. …

Two closely related diaryl acylsulfonamides were recently reported as potent antitumor
agents against a broad spectrum of human tumor xenografts (colon, lung, breast, ovary, and …

Nanoparticle biodistribution in vivo is an essential component to the success of nanoparticle-based
drug delivery systems. Previous studies with fluorescently labeled expansile …

One of the foremost challenges in translating nanoparticle technologies to the clinic is the
requirement to produce materials on a large-scale. Scaling nanoparticle production methods is …

Inhibition of angiogenesis may have wide use in the treatment of cancer; however, this approach
alone will not cause tumor regression but may only slow the growth of solid tumors. The …

Inflammatory breast cancer (IBC) is an understudied and aggressive form of breast cancer
with a poor prognosis, accounting for 2-6% of new breast cancer diagnoses but 10% of all …