Voltage-gated sodium channels are essential for the initiation and propagation of the action
potential in neurons and other excitable cells. Because of their critical roles in electrical …

Pyrethroid insecticides are widely used as one of the most effective control measures in the
global fight against agricultural arthropod pests and mosquito-borne diseases, including …

Potassium channels are tetrameric membrane proteins that selectively conduct K+ across
cellular membranes. With 78 family members, K+ channels make up about half of the …

Voltage-gated sodium channels are critical for the generation and propagation of action
potentials. They are the primary target of several classes of insecticides, including DDT, …

… The project on the mechanism of knockdown resistance to pyrethroids in Aedes aegypti is
supported by a grant from NIH (GM 57440) to Ke Dong and Boris S. Zhorov. We thank past …

… Tikhonov, Boris S. Zhorov; Mechanism of sodium channel block by local anesthetics,
antiarrhythmics, and anticonvulsants. J Gen Physiol 3 April 2017; 149 (4): 465–481. doi: https://doi.…

In the last decade, the idea of common organization of certain ion channel families exhibiting
diverse physiological and pharmacological properties has received strong experimental …

A large body of experimental data on Na + channels is available, but the interpretation of these
data in structural terms is difficult in the absence of a high-resolution structure. Essentially …

1,4-Dihydropyridines (DHPs) constitute a major class of ligands for L-type Ca 2+ channels (LTCC).
The DHPs have a boat-like, six-membered ring with an NH group at the stern, an …

The X-ray structure of the bacterial sodium channel NavAb provides a new template for the
study of sodium and calcium channels. Unlike potassium channels, NavAb contains P2 …