Upregulation of neuronal nicotinic acetylcholine receptors (AChRs) is a venerable result of
chronic exposure to nicotine; but it is one of several consequences of pharmacological …

Understanding why the quit rate among smokers of menthol cigarettes is lower than non-menthol
smokers requires identifying the neurons that are altered by nicotine, menthol, and …

Introduction Although the use of combustible cigarettes has decreased in many urban
regions of America, the use of electronic nicotine delivery systems (ENDS) has dramatically …

Upregulation of β2 subunit-containing (β2*) nicotinic acetylcholine receptors (nAChRs) is
implicated in several aspects of nicotine addiction, and menthol cigarette smokers tend to …

Glycosylphosphatidylinositol-anchored neurotoxin-like receptor binding proteins, such as lynx
modulators, are topologically positioned to exert pharmacological effects by binding to the …

Background Electronic nicotine delivery systems (ENDS) differ from combustible cigarettes
given that nicotine-salt or nicotine-freebase may be used depending on the product. We have …

Chronic exposure to nicotine up-regulates high sensitivity nicotinic acetylcholine receptors (nAChRs)
in the brain. This up-regulation partially underlies addiction and may also …

While nicotine is the primary addictive component in tobacco products, additional flavors
have become a concern with the growing popularity of electronic nicotine delivery systems (…

Retrospective epidemiological studies show an inverse correlation between susceptibility to
Parkinson's disease and a person's history of tobacco use. Animal model studies suggest …

Chronic exposure to nicotine results in an upregulation of neuronal nicotinic acetylcholine
receptors (nAChRs) at the cellular plasma membrane. nAChR upregulation occurs via nicotine…