User profiles for Bret D Wallace
Bret D. WallaceSymberix, Inc. Verified email at symberix.com Cited by 2426 |
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme
BD Wallace, H Wang, KT Lane, JE Scott, J Orans… - Science, 2010 - science.org
The dose-limiting side effect of the common colon cancer chemotherapeutic CPT-11 is severe
diarrhea caused by symbiotic bacterial β-glucuronidases that reactivate the drug in the gut…
diarrhea caused by symbiotic bacterial β-glucuronidases that reactivate the drug in the gut…
[PDF][PDF] Structure and inhibition of microbiome β-glucuronidases essential to the alleviation of cancer drug toxicity
BD Wallace, AB Roberts, RM Pollet, JD Ingle… - Chemistry & biology, 2015 - cell.com
The selective inhibition of bacterial β-glucuronidases was recently shown to alleviate drug-induced
gastrointestinal toxicity in mice, including the damage caused by the widely used …
gastrointestinal toxicity in mice, including the damage caused by the widely used …
Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice
A LoGuidice, BD Wallace, L Bendel, MR Redinbo… - … of Pharmacology and …, 2012 - ASPET
Small intestinal mucosal injury is a frequent adverse effect caused by nonsteroidal anti-inflammatory
drugs (NSAIDs). The underlying mechanisms are not completely understood, but …
drugs (NSAIDs). The underlying mechanisms are not completely understood, but …
Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy
…, KA Biernat, WG Walton, BD Wallace… - Proceedings of the …, 2020 - National Acad Sciences
Irinotecan treats a range of solid tumors, but its effectiveness is severely limited by gastrointestinal
(GI) tract toxicity caused by gut bacterial β-glucuronidase (GUS) enzymes. Targeted …
(GI) tract toxicity caused by gut bacterial β-glucuronidase (GUS) enzymes. Targeted …
Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity
AB Roberts, BD Wallace, MK Venkatesh, S Mani… - Molecular …, 2013 - ASPET
Bacterial β-glucuronidases expressed by the symbiotic intestinal microbiota appear to play
important roles in drug-induced epithelial cell toxicity in the gastrointestinal (GI) tract. For the …
important roles in drug-induced epithelial cell toxicity in the gastrointestinal (GI) tract. For the …
[PDF][PDF] Endogenous DNA 3′ blocks are vulnerabilities for BRCA1 and BRCA2 deficiency and are reversed by the APE2 nuclease
…, N Hustedt, SE Rossi, BD Wallace, D Setiaputra… - Molecular cell, 2020 - cell.com
The APEX2 gene encodes APE2, a nuclease related to APE1, the apurinic/apyrimidinic
endonuclease acting in base excision repair. Loss of APE2 is lethal in cells with mutated BRCA1 …
endonuclease acting in base excision repair. Loss of APE2 is lethal in cells with mutated BRCA1 …
Recognition and repair of chemically heterogeneous structures at DNA ends
…, MJ Schellenberg, BD Wallace… - Environmental and …, 2015 - Wiley Online Library
Exposure to environmental toxicants and stressors, radiation, pharmaceutical drugs, inflammation,
cellular respiration, and routine DNA metabolism all lead to the production of cytotoxic …
cellular respiration, and routine DNA metabolism all lead to the production of cytotoxic …
Targeting the pregnane X receptor using microbial metabolite mimicry
…, J Brtko, L Toporova, A Schön, BD Wallace… - EMBO molecular …, 2020 - embopress.org
The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential
roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have …
roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have …
Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective
BD Wallace, MR Redinbo - Drug metabolism reviews, 2013 - Taylor & Francis
Xenobiotic compounds undergo a critical range of biotransformations performed by the phase
I, II, and III drug-metabolizing enzymes. The oxidation, conjugation, and transportation of …
I, II, and III drug-metabolizing enzymes. The oxidation, conjugation, and transportation of …
APE2 Zf-GRF facilitates 3′-5′ resection of DNA damage following oxidative stress
BD Wallace, Z Berman, GA Mueller… - Proceedings of the …, 2017 - National Acad Sciences
The Xenopus laevis APE2 (apurinic/apyrimidinic endonuclease 2) nuclease participates in 3′-5′
nucleolytic resection of oxidative DNA damage and activation of the ATR-Chk1 DNA …
nucleolytic resection of oxidative DNA damage and activation of the ATR-Chk1 DNA …