Predicting Zika virus structural biology: Challenges and opportunities for intervention
BD Cox, RA Stanton… - Antiviral Chemistry and …, 2015 - journals.sagepub.com
Background Zika virus is an emerging crisis as infection is implicated in severe neurological
disorders—Guillain–Barré syndrome and fetal microcephaly. There are currently no …
disorders—Guillain–Barré syndrome and fetal microcephaly. There are currently no …
Synthesis of sulfamoylbenzamide derivatives as HBV capsid assembly effector
O Sari, S Boucle, BD Cox, T Ozturk, OO Russell… - European journal of …, 2017 - Elsevier
The synthesis of novel series of sulfamoylbenzamides as HBV capsid assembly effector is
reported. The structure was divided into five parts which were independently modified as part …
reported. The structure was divided into five parts which were independently modified as part …
[HTML][HTML] Defining the communication between agonist and coactivator binding in the retinoid X receptor α ligand binding domain
LAJ Boerma, G Xia, C Qui, BD Cox… - Journal of Biological …, 2014 - ASBMB
Retinoid X receptors (RXRs) are obligate partners for several other nuclear receptors, and
they play a key role in several signaling processes. Despite being a promiscuous heterodimer …
they play a key role in several signaling processes. Despite being a promiscuous heterodimer …
Pyrazolo-piperidines exhibit dual inhibition of CCR5/CXCR4 HIV entry and reverse transcriptase
BD Cox, AR Prosser, Y Sun, Z Li, S Lee… - ACS medicinal …, 2015 - ACS Publications
We report novel anti-HIV-1 agents with combined dual host–pathogen pharmacology. Lead
compound 3, composed of a pyrazole-piperidine core, exhibits three concurrent …
compound 3, composed of a pyrazole-piperidine core, exhibits three concurrent …
The mechanism of action of hepatitis B virus capsid assembly modulators can be predicted from binding to early assembly intermediates
Interfering with the self-assembly of virus nucleocapsids is a promising approach for the
development of novel antiviral agents. Applied to hepatitis B virus (HBV), this approach has led …
development of novel antiviral agents. Applied to hepatitis B virus (HBV), this approach has led …
[HTML][HTML] Oats lower age-related systemic chronic inflammation (iAge) in adults at risk for cardiovascular disease
Despite being largely preventable, cardiovascular disease (CVD) is still the leading cause
of death globally. Recent studies suggest that the immune system, particularly a form of …
of death globally. Recent studies suggest that the immune system, particularly a form of …
Nucleoside analogs with selective antiviral activity against dengue fever and Japanese encephalitis viruses
Dengue virus (DENV) and Japanese encephalitis virus (JEV) are important arthropod-borne
viruses from the Flaviviridae family. DENV is a global public health problem with significant …
viruses from the Flaviviridae family. DENV is a global public health problem with significant …
[HTML][HTML] Jak inhibitors modulate production of replication-competent zika virus in human hofbauer, trophoblasts, and neuroblastoma cells
C Gavegnano, LC Bassit, BD Cox, HM Hsiao… - Pathogens & …, 2017 - ncbi.nlm.nih.gov
Zika Virus (ZIKV) is a flavivirus that has been implicated in causing brain deformations, birth
defects, and microcephaly in fetuses, and associated with Guillain-Barre syndrome. …
defects, and microcephaly in fetuses, and associated with Guillain-Barre syndrome. …
Anti‐HIV Small‐Molecule Binding in the Peptide Subpocket of the CXCR4: CVX15 Crystal Structure
BD Cox, AR Prosser, BM Katzman, AA Alcaraz… - …, 2014 - Wiley Online Library
The CXC chemokine receptor 4 (CXCR4) is involved in chemotaxis and serves as a coreceptor
for T‐tropic HIV‐1 viral entry, thus making this receptor an attractive drug target. Recently…
for T‐tropic HIV‐1 viral entry, thus making this receptor an attractive drug target. Recently…
Structure, Energetics, and Dynamics of Binding Coactivator Peptide to the Human Retinoid X Receptor α Ligand Binding Domain Complex with 9-cis-Retinoic Acid
G Xia, LAJ Boerma, BD Cox, C Qiu, S Kang… - Biochemistry, 2011 - ACS Publications
Retinoid X receptors (RXRs) are ligand-dependent nuclear receptors, which are activated
by the potent agonist 9-cis-retinoic acid (9cRA). 9cRA binds to the ligand binding domain (LBD…
by the potent agonist 9-cis-retinoic acid (9cRA). 9cRA binds to the ligand binding domain (LBD…