The synthesis of a new retinoid, N-(4-hydroxyphenyl)-all-trans-retinamide, which has useful
biological properties, is described. This retinoid was more potent than retinyl acetate in …

Indole-3-carbinol, a component of cruciferous vegetables, was evaluated for it efficacy in the
prevention of chemically-induced mammary tumors using three different protocols. Because …

Epidemiological studies have shown that nonsteroidal anti-inflammatory drugs (NSAIDs) may
have a role in the prevention of human cancers. A number of preclinical studies have also …

Curcumin and quercetin were evaluated in rats for their ability to modulate the carcinogenic
activity of azoxy-methane (AOM) in the colon and 7, 12-dimethyl-benz[a]anthracene (DMBA) …

In the NCI, Chemoprevention Branch drug development program, potential chemopreventive
agents are evaluated for efficacy against chemical carcinogen–induced tumors in animal …

Exisulind (Aptosyn) is a novel antineoplastic drug being developed for the prevention and
treatment of precancerous and malignant diseases. In colon tumor cells, the drug induces …

Genes differentially expressed by tumor cells represent promising drug targets for anti-cancer
therapy. Such candidate genes need to be validated in appropriate animal models. This …

… However, this effect can apparently be ameliorated without losing efficacy either by combining
it with omeprazole or altering the dosing schedule (RA Lubet and CJ Grubbs; unpublished …

In an initial study to determine if rosiglitazone had chemopreventive activity, Fischer‐344
female rats were administered twice weekly doses of hydroxybutyl(butyl)nitrosamine (OH‐BBN)…

Because hormones of pregnancy are thought to alter the mammary gland such that the
epithelial cells are less susceptible to future carcinogenic insults, the present study was …