Neuroactive steroids, including endogenously occurring metabolites of progesterone and
deoxycorticosterone as well as their synthetic derivatives, are positive allosteric modulators of …

There is little primate risk factor data in the literature evaluating the relationship between
proposed mechanisms of PPAR agonist-induced hepatocarcinogenesis at clinically relevant …

… , anxiolytics, and sedative−hypnotics such as benzodiazepines (BZ) and barbiturates mediate
their action by binding to distinct allosteric modulatory sites on the GABA A receptor−Cl - …

Purpose The paradigm shift in cancer treatment from cytotoxic drugs to tumor targeted
therapies poses new challenges, including optimization of dose and schedule based on a …

The interaction of three types of steroids with the GABA A recognition site labeled by the
antagonist ligand [ 3 H]SR 95531 was evaluated in rat brain cortical membranes. The first type is …

Neuroactive steroids allosterically inhibit [ 35 S ]t- butylbicyclophosphorothionate ([ 35 S]TBPS)
and enhance [ 3 H]flunitrazepam binding to the GABA A receptor complex. In the …

Background— Urotensin-II (U-II) is an endogenous peptide upregulated in failing hearts. To
date, insights into the myocardial actions of U-II have been obscured by its potent …

Background In dogs, the diestrus phase is considerably longer than in most domestic animals,
and is characterized by high circulating progesterone concentrations that may influence …

… JE Hawkinson, JA Drewe, CL Kimbrough, JS Chen, DJ Hogenkamp, NC Lan, KW Gee,
KZ Shen, ER Whittemore and RM Woodward …

Depletion of Kupffer cells, known to modulate chemical-induced hepatocellular injury, has
not been studied with regard to biliary epithelial injury. Here, the authors investigated the …