In the past decade, substantial evidence supports the paradigm that stem cells exert their
reparative and regenerative effects, in large part, through the release of biologically active …

… Hodgkinson and colleagues review the current status of knowledge with respect to the
genetic modifications being explored as a means to improve mesenchymal stem cell therapy for …

The human heart has a limited capacity to regenerate lost or damaged cardiomyocytes after
cardiac insult. Instead, myocardial injury is characterized by extensive cardiac remodeling …

Rationale: A major goal for the treatment of heart tissue damaged by cardiac injury is to
develop strategies for restoring healthy heart muscle through the regeneration and repair of …

Objective— Diabetes is a major risk factor for coronary heart disease. Accumulation of advanced
glycation end-products (AGEs) attributable to hyperglycemia in diabetics promotes the …

Rationale: Atherosclerotic lesions express matrix metalloproteinase (MMP)8, which possesses
proteolytic activity on matrix proteins particularly fibrillar collagens and on nonmatrix …

REGNANCY is accompanied by major LSkkkk in the uterine blood vessels and ovarian veins.
This paper reports on the author's observations of the hemodynamics of the ovarian veins …

Rationale: Direct reprogramming of cardiac fibroblasts to cardiomyocytes has recently
emerged as a novel and promising approach to regenerate the injured myocardium. We have …

We have recently shown that a combination of microRNAs, miR combo, can directly reprogram
cardiac fibroblasts into functional cardiomyocytes in vitro and in vivo. Reprogramming of …

Fibrinogen has been implicated in atherosclerosis; in part by activating the lipopolysaccharide
(LPS) receptor Toll-like receptor 4 (TLR4). The fibrinogen-TLR4 signalling pathway …