Production of IgM hexamers by normal and autoimmune B cells: implications for the physiologic role of hexameric IgM

CT Hughey, JW Brewer, AD Colosia… - The Journal of …, 1998 - journals.aai.org
Secreted IgM is predominantly found as pentameric molecules, but IgM can also be secreted
as hexamers by B cell lines. Murine hexamers activate the complement cascade more …

Functional effects of a naturally occurring amino acid substitution in human thymidylate synthase.

CT Hughey, KW Barbour, FG Berger, SH Berger - Molecular pharmacology, 1993 - ASPET
A major mechanism underlying the cytotoxicity of fluoropyrimidine analogs such as 5-fluorouracil
and 5-fluoro-2'-deoxyuridine (FdUrd) occurs via the formation of 5-fluoro-2'-…

The diagnostic challenge of the sequelae of acute pancreatitis on CT imaging: a pictorial essay

M Hughey, M Taffel, RK Zeman, S Patel, MC Hill - Abdominal Radiology, 2017 - Springer
Purpose The purpose of the study was to present a pictorial review of the long-term sequelae
of acute pancreatitis on CT imaging as these findings can cause diagnostic confusion in …

Genetic variation in thymidylate synthase confers resistance to 5-fluorodeoxyuridine

CT Hughey, KW Barbour, FG Berger… - Novel Approaches to …, 1993 - Springer
The human colorectal tumor cell line HCT 116 was resistant to the cytotoxic effects of 5-fluorodeoxyuridine
(FdUrd). The response to FdUrd was increased only slightly by the presence …

[HTML][HTML] Machine learning identifies a compact gene set for monitoring the circadian clock in human blood

JJ Hughey - Genome medicine, 2017 - Springer
… Having established a baseline for predicting CT in human blood, we next investigated
how predictions of CT were affected by the perturbation condition in each dataset. Here we …

[HTML][HTML] Mind the gap: The impact of neuromuscular electrical stimulation on the inter recti distance associated with diastasis recti abdominis

KD Alvarez, JM Guilarte, CT Hughey, AN Oceguera… - 2023 - digitalcommons.pcom.edu
OBJECTIVES: This study aims to determine if NMES will reduce the magnitude of the DRA
via analysis of the inter-recti distance and if this will impact the stiffness of the linea alba as …

Making everyday microaggressions: An exploratory experimental vignette study on the presence and power of racial microaggressions

MW Hughey, J Rees, DR Goss, ML Rosino… - Sociological …, 2017 - Wiley Online Library
… As a consequence, the greater likelihood of holding in-group racial trust may be driven
by exposure to people and objects coded as culturally “black” (Hughey 2012a) or collective …

Racial authenticity and familial acceptance among transracial adoptees: A bothersome bargain of belonging

DR Goss, WC Byrd, MW Hughey - Symbolic Interaction, 2017 - Wiley Online Library
… We deploy the concepts of “color capital” and “white debt” (Hughey 2012a) to indicate how
transracial families reinforce particular stereotypes and views of communities of color, certain …

Biochemical factors influencing the lack of modulation of 5-fluoropyrimidines by folinic acid in human colonic tumor cell lines.

CT Hughey - 1993 - elibrary.ru
Folinic acid (CF) may enhance the cytotoxic action of 5-fluoropyrimidines (FPs) in mammalian
tumor cell lines and in human tumors. Cytotoxicity derives from the binding of the FP …

Suicide prevention skills, confidence and training: Results from the Zero Suicide Workforce Survey of behavioral health care professionals

…, P Graham, N Hubbard, K Hughey… - SAGE open …, 2020 - journals.sagepub.com
… Survey was administered electronically to behavioral health care professionals at six
behavioral health treatment centers with both inpatient and ambulatory programs in Connecticut, …