… ß (CA Austin, unpublished observations). Indeed, different phosphorylation states could
produce separate functional ‘‘pools’’ of DNA topoisomerase II.The fact that there are multiple …

Importance Serious illness impairs function and threatens survival. Patients facing serious
illness value shared decision making, yet few decision aids address the needs of this …

Visual impairment, although not routinely assessed, is an important risk factor for falls and
hip fracture in older people. Impaired vision is highly prevalent and commonly unreported in …

We report for the first time the use of a selective small-molecule inhibitor of DNA repair to
potentiate topoisomerase II (topo II) poisons, identifying DNA-dependent protein kinase (DNA-…

The expression of DNA topoisomerase II α and β genes was studied in murine normal tissues.
Northern blot analysis using probes specific for the two genes showed that the patterns of …

Background The histone variant histone H2A.X comprises up to 25% of the H2A complement
in mammalian cells. It is rapidly phosphorylated following exposure of cells to double-…

Type II topoisomerases are required for the management of DNA superhelicity and chromosome
segregation, and serve as frontline targets for a variety of small-molecule therapeutics. …

The cardiac glycosides digitoxin (1) and digoxin (3) have been used in cardiac diseases for
many years. During this time several reports have suggested the possible use of digitalis in …

… The next day, the medium was removed using a VSpin (Velocity 11, Menlo Park, CA) fitted
with a modified bucket allowing the 384-well plate to be mounted inverted over a catch basin …

Topoisomerase poisons such as the epipodophyllotoxin etoposide are widely used effective
cytotoxic anticancer agents. However, they are associated with the development of therapy-…