User profiles for C. Beeton
 | Christine BeetonBaylor College of Medicine Verified email at bcm.edu Cited by 7625 |
K+ channels as targets for specific immunomodulation
The voltage-gated Kv1.3 channel and the Ca 2+ -activated IKCa1 K + channel are expressed
in T cells in a distinct pattern that depends on the state of lymphocyte activation and …
in T cells in a distinct pattern that depends on the state of lymphocyte activation and …
Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases
… the C-terminus of ShK-170 and improve its manufacturing aspects, we replaced the C-… The
new analog, ShK-186 (Beeton et al., 2006), retains the selectivity and potency profile of ShK-…
new analog, ShK-186 (Beeton et al., 2006), retains the selectivity and potency profile of ShK-…
Potassium channels as therapeutic targets for autoimmune disorders.
In human T-lymphocytes, the voltage-gated Kv1. 3 channel and the Ca (2+)-activated IKCa1
channel play an important role in Ca2+ signaling, activation, adhesion and migration and …
channel play an important role in Ca2+ signaling, activation, adhesion and migration and …
Kv1. 3 channels are a therapeutic target for T cell-mediated autoimmune diseases
Autoreactive memory T lymphocytes are implicated in the pathogenesis of autoimmune
diseases. Here we demonstrate that disease-associated autoreactive T cells from patients with …
diseases. Here we demonstrate that disease-associated autoreactive T cells from patients with …
Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation
…, FU Müller, A El-Armouche, N Tony Eissa, C Beeton… - Circulation, 2018 - Am Heart Assoc
… C, Representative telemetry ECG recording demonstrated sinus rhythm in Ctl mice and
premature atrial contractions (PACs, indicated by arrows) in CM-KI mice. D, Box plot …
premature atrial contractions (PACs, indicated by arrows) in CM-KI mice. D, Box plot …
[HTML][HTML] The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS
…, S Yun, M Pennington, C Beeton… - The Journal of …, 2003 - Am Soc Clin Investig
Through a combination of fluorescence microscopy and patch-clamp analysis we have identified
a striking alteration in K + channel expression in terminally differentiated human CCR7 …
a striking alteration in K + channel expression in terminally differentiated human CCR7 …
Selective blockade of T lymphocyte K+ channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis
… (B and C) Treatment of moderate (B) and severe (C) EAE induced by different batches of
PAS cells with varying encephalitogenic potencies. Rats were injected with saline or blockers …
PAS cells with varying encephalitogenic potencies. Rats were injected with saline or blockers …
Targeting effector memory T cells with a selective peptide inhibitor of Kv1. 3 channels for therapy of autoimmune diseases
… To examine its stability, we incubated ShK(L5) in rat plasma or in PBS containing 2% rat
plasma at 37C for varying durations and then measured Kv1.3 blocking activity. In both sets of …
plasma at 37C for varying durations and then measured Kv1.3 blocking activity. In both sets of …
[HTML][HTML] AAV-CRISPR gene editing is negated by pre-existing immunity to Cas9
… (C) CD8 mRNA expression between mice immunized against ovalbumin and SaCas9
measured by qPCR. (D) Representative TUNEL staining in mouse liver sections. (E) Serum …
measured by qPCR. (D) Representative TUNEL staining in mouse liver sections. (E) Serum …
The voltage-gated potassium channel Kv1. 3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain
… CD4 were incubated at 4C for 48 h and then incubated overnight at 4C in Alexa Fluor 555- …
4C in blocking solution (PBS/5% goat serum/5% bovine serumalbumin/0.1% sodium azide). …
4C in blocking solution (PBS/5% goat serum/5% bovine serumalbumin/0.1% sodium azide). …