Insights into the molecular evolution of oxytocin receptor ligand binding
J Koehbach, T Stockner, C Bergmayr… - Biochemical Society …, 2013 - portlandpress.com
… It contains the typical six-residue N-terminal ring, but has an additional two residues at its
C-terminus. The evolutionary perspective of this modification, its influence on ligand binding …
C-terminus. The evolutionary perspective of this modification, its influence on ligand binding …
[HTML][HTML] A distinct microbiota composition is associated with protection from food allergy in an oral mouse immunization model
SC Diesner, C Bergmayr, B Pfitzner, V Assmann… - Clinical …, 2016 - Elsevier
In our mouse model, gastric acid-suppression is associated with antigen-specific IgE and
anaphylaxis development. We repeatedly observed non-responder animals protected from …
anaphylaxis development. We repeatedly observed non-responder animals protected from …
Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species
… (C and D) Functional screen of oxytocin analogs 1 to 10 (C) and vasopressin analogs 11 to
16 (D) at the human OT receptor (hOTR), hV1aR, and hV1bR using the fluorescent imaging …
16 (D) at the human OT receptor (hOTR), hV1aR, and hV1bR using the fluorescent imaging …
[HTML][HTML] Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin
…, L Dürrauer, H Xiang, D Gharib, C Bergmayr… - Chemical …, 2021 - pubs.rsc.org
… Considering the potent agonism of the VP dimers, we also designed and synthesized N-
to C-terminal cyclized VP and OT dimers with the aim of creating metabolically more stable …
to C-terminal cyclized VP and OT dimers with the aim of creating metabolically more stable …
[HTML][HTML] Recruitment of a cytoplasmic chaperone relay by the A2A adenosine receptor
C Bergmayr, P Thurner, S Keuerleber… - Journal of Biological …, 2013 - ASBMB
… ), the A 2A receptor has an unusually long intracellular C-terminal tail (122 amino acids of
the human A 2A receptor compared with only 34 residues in the C terminus of the human A 1 …
the human A 2A receptor compared with only 34 residues in the C terminus of the human A 1 …
[HTML][HTML] Characterization of Vibrio cholerae neuraminidase as an immunomodulator for novel formulation of oral allergy immunotherapy
SC Diesner, C Bergmayr, XY Wang, D Heiden… - Clinical …, 2018 - Elsevier
To improve current mucosal allergen immunotherapy Vibrio cholerae neuraminidase (NA)
was evaluated as a novel epithelial targeting molecule for functionalization of allergen-loaded…
was evaluated as a novel epithelial targeting molecule for functionalization of allergen-loaded…
[HTML][HTML] Janus-faced Acrolein prevents allergy but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory …
…, C Bergmayr, S Meitz, S Buchleitner, C Stremnitzer… - Scientific reports, 2017 - nature.com
… In our BALB/c mouse tumor model using syngenic D2F2 mammary cancer cells as a model
of any type of cancer, acrolein exposure resulted in enhanced tumor growth associated with …
of any type of cancer, acrolein exposure resulted in enhanced tumor growth associated with …
Repurposing treprostinil for enhancing hematopoietic progenitor cell transplantation
Z Kazemi, C Bergmayr, M Prchal-Murphy… - Molecular …, 2016 - ASPET
… 94C, annealing for 30 seconds at 55C, extension for 90 seconds at 72C, followed by a final
extension for 5 minutes at 72C… at 95C, annealing at 60C for 30 seconds, extension 72C for 30 …
extension for 5 minutes at 72C… at 95C, annealing at 60C for 30 seconds, extension 72C for 30 …
[HTML][HTML] Treprostinil reduces endothelial damage in murine sinusoidal obstruction syndrome
M Themanns, F Koban, C Bergmayr, A Chrzan… - Journal of Molecular …, 2019 - Springer
… 4c and 5c) occurred more frequently in animals that had undergone allogeneic … /C mice
not subjected to any treatment (Fig. 4d–g). The reason for this preexisting pathology is not clear. …
not subjected to any treatment (Fig. 4d–g). The reason for this preexisting pathology is not clear. …
[HTML][HTML] Immune effects of the nitrated food allergen beta-lactoglobulin in an experimental food allergy model
…, GJ Oostingh, E Fuerst, J Fazekas-Singer, C Bergmayr… - Nutrients, 2019 - mdpi.com
… Microtiter plates were coated with capture antibody overnight at 4 C and blocked for 1 h at
RT. Samples and standards were incubated overnight at 4 C. After the addition of detection …
RT. Samples and standards were incubated overnight at 4 C. After the addition of detection …