I2-imidazoline binding sites and monoamine oxidase activity in human postmortem brain from patients with Parkinson's disease

C Gargalidis-Moudanos, N Pizzinat… - Neurochemistry …, 1997 - Elsevier
I 2 -imidazoline binding site (I 2 BS) has been identified with a regulatory site located on a
sub-population of monoamine oxidase (MAO)-A and -B. Previous studies showed a …

The elusive family of imidazoline binding sites

A Parini, CG Moudanos, N Pizzinat… - Trends in pharmacological …, 1996 - cell.com
Various compounds with an imidazoline or guanidinium moiety (Fig. 1) elicit a number of ph~~
r~~ ucolugic~~ l cffccts via interactions with ru-adrenoceptors and ion transport system&. …

Imidazoline-guanidine site: a subtype of imidazoline receptors

…, F Tesson, V Lachaud, C Gargalidis-Moudanos… - Therapie, 1992 - europepmc.org
Since the demonstration that imidazoline and guanidinium alpha-2 adrenergic agonists induce
some of their functional effects by a" nonadrenergic" mechanism, many efforts have been …

I2-imidazoline binding sites: relationship with different monoamine oxidase domains and identification of histidine residues mediating ligand binding regulation by H+ …

…, F Tesson, C Gargalidis-Moudanos… - … of Pharmacology and …, 1996 - ASPET
We have shown that I2-imidazoline binding sites (I2BSs) are located on both monoamine
oxidases A (MAO-A) and B (MAO-B) and are selectively regulated by H+ and K+ in vitro. In the …

Predominant expression of monoamine oxidase B isoform in rabbit renal proximal tubule: Regulation by I2 imidazoline ligands in intact cells

C Gargalidis-Moudanos, A Remaury, N Pizzinat… - Molecular …, 1997 - ASPET
Previous studies have shown that a subpopulation of the catecholamine-degrading enzymes
monoamine oxidase (MAO) A and B holds a previously unknown regulatory site, the I 2 -…

Selectivity of rilmenidine for I1-imidazoline-binding sites in rabbit proximal tubule cells

C Gargalidis-Moudanos, A Parmi - Journal of cardiovascular …, 1995 - journals.lww.com
Imidazoline and imidazoline-like compounds may elicit their pharmacological activities
through the interaction with three membrane proteins: α 2-adrenergic receptors (α 2-AR). I 1-…

[CITATION][C] L 5‐IMIDAZOLINE‐GUANIDINIUM RECEPTIVE SITE (IGRS): MITOCHONDRIAL DISTRIBUTION AND REGULATION PROPERTIES

…, I Limon, C GargalidisMoudanos - Fundamental & …, 1992 - Wiley Online Library
Several studies have shown that imidazoline and guanidinium alpha-2 adrenergic compounds
elicit some of their functional activities by a nonadrenergic mechanism (1, 2). In 1984, …

[CITATION][C] Renal monoamine oxidases: potential role in the long term regulation of blood pressure

C GargalidisMoudanos, A Remaury… - Fundamental & …, 1997 - Wiley Online Library
Catecholamines play a major role in the short-term regulation of blood pressure by acting
on the cardiac output and the vascular tone. In addition, noradrenaline and dopamine also …

Reactive oxygen species production by monoamine oxidases in intact cells

…, N Copin, C Vindis, A Parini, C Cambon - … archives of pharmacology, 1999 - Springer
… Using enzyme assay and Western blot analysis, we have previously shown that rabbit
proximal tubule cells contain almost exclusively MAO B (Gargalidis-Moudanos et al. 1997) whilst …

[CITATION][C] [3H] idazoxan binds to mitochondrial I2 imidazoline binding sites in isolated cells from rabbit kidney proximal tubule.

C Gargalidis-Moudanos, A Parini - … of the New York Academy of …, 1995 - europepmc.org
Gargalidis-Moudanos C 1 , … Tesson F, Prip-Buus C, Lemoine A, Pegorier JP, Parini A …