A novel and generally applicable method for determining structures of membrane proteins
in solution via small‐angle neutron scattering (SANS) is presented. Common detergents for …

Phosphorylation of hormone‐sensitive lipase by protein kinase A in vitro promotes an increase
in its hydrophobic surface area - Krintel - 2009 - The FEBS Journal - Wiley Online Library …

Background Hormone-sensitive lipase (HSL) is a key enzyme in the mobilization of fatty acids
from stored triacylglycerols. Its activity is regulated by reversible protein phosphorylation. …

Positive allosteric modulators of ionotropic glutamate receptors are potential compounds for
treatment of cognitive disorders, eg, Alzheimer’s disease. The modulators bind within the …

The α4β2 subtype of the nicotinic acetylcholine receptor has been pursued as a drug target
for treatment of psychiatric and neurodegenerative disorders and smoking cessation aids for …

Accumulating evidence suggests that dysregulated glycerol metabolism contributes to the
pathophysiology of obesity and type 2 diabetes. Glycerol efflux from adipocytes is regulated by …

… Maria Kristensen and Peter Naur initially produced GluA2 LBD-L483Y-N754S; Christian
Krintel performed ITC with modulators and structural investigations on the BPAM-97 complex; …

… , Waltham, MA) using 1 cycle of 5 min at 94C, and then 22–30 cycles each of 60 s at 94C,
60 s at 55–64C (annealing temperature optimized for the individual genes), and 60 s at 65…

… They are tetrameric ligand-gated ion channels with each subunit consisting of a flexible
intracellular C-terminal … Christian Krintel and Pierre Francotte contributed equally to this work. …

Background Patients with bladder pain syndrome experience debilitating pain and extreme
frequency of urination. Numerous therapeutic approaches have been tested, but as the …