The multikinase inhibitor sorafenib is currently the treatment of reference for advanced
hepatocellular carcinoma (HCC). In our report, we examined the cytotoxic effects of sorafenib on …

… Sorafenib treatment of Balb/c nude mice that received tumour xenografts derived from HCC
cells with reduced Rb levels resulted in complete tumour regression in 50% of the animals …

Sorafenib is currently the medical treatment of reference for hepatocellular carcinoma (HCC),
but it is not known whether sorafenib is equally active in all HCC. Here, our aim was to …

… c Immunoblot analysis of the expression of the MT1 protein. Protein extracts were prepared
from Huh7 cells treated for 4 to 18 h with 10 μM sorafenib. d MT1G mRNA levels were …

Sorafenib is the first line treatment for advanced hepatocellular carcinoma (HCC). We explored
its impact on the proteostasis of cancer cells, ie the processes that regulate the synthesis, …

… C. A heatmap showing the gene expression of ferroptosis genes in HNSCC tumors ranked
according to their increasing mRNA expression of SLC7A11. The gene expression was …

… All samples were kept frozen at −80C. The corresponding protocol was approved by the Comité
de Protection des Personnes 2 Nord-… All inhibitors were kept as stocks in DMSO at −20C. …

… 2C). We did not detect any change in the levels of BAD mRNA in SMC exposed to urea (Fig. …
(C) BAD protein stability. Aortic SMC were treated for 30 min with 50 μM cycloheximide and …

… /ml Ham's F10 medium with 5 μM CuSO 4 at 37C for 24 h. Cu 2+ was not removed after …
at 4C for 30 min. After centrifugation at 18,000g for 5 min, the supernatant was kept at −80C. …

Ferroptosis is a form of cell death that has recently been reported during exposure to erastin,
a chemical compound identified in a screen for molecules able to kill cancer cells carrying …