Those corticosteroids(C21) in which the angular methyl group at Cl8 is oxidised either to a
primary alcohol or to an aldehyde group possess unique structural features elicited by the …

The mineralocorticoid receptor (MR) is primarily localized in the cytoplasm of the cell in the
absence of ligand. The first step in the genomic-dependent mechanism of action of …

Antiglucocorticoids that act as antagonists at the glucocorticoid receptor (GR) level may be
used to block or modulate the undesirable effects of glucocorticoid excess (from endogenous …

In the rat, the conformationally highly bent steroid 21-hydroxy-6,19-oxidoprogesterone
efficiently displaces [ 3 H]corticosterone from thymus-glucocorticoid receptors and blocks type II …

The effect of progesterone and six other C21-deoxysteroids on renal sodium retention by
male adrenalectomized rats was compared with the effect exerted by the natural corticoids …

Sulfur-bridged pregnanes 6,19-epithioprogesterone, 21-hydroxy-6,19-epithioprogesterone,
and the corresponding sulfoxides and sulfones were synthesized and tested as blockers of …

Infusion of endothelin-1 (ET-1) into rats increased adrenal mitochondrial synthesis of aldosterone
from deoxycorticosterone and the adrenal cytosolic content of aldosterone. The dose-…

11β-hydroxyprogesterone (HOP) and 11-ketoprogesterone (KP) are reversible components
of a shuttle pair whose interconversion in rat liver is catalyzed by isoform-1 of 11β-…

Rat adrenal glands convert 2-methyl-1,2-bis(3-pyridyl)-1-propanone (SU-4885) in vitro to a
product with physical and chemical properties indicating the reduction to 2-methyl-1,2-bis(3-…

We have demonstrated previously that a planar conformation of the molecular frame is
required for steroids to acquire optimal sodium-retaining activity and binding properties to the …