Extracellular ATP, at micromolar concentrations, induces significant functional changes in a
wide variety of cells and tissues. ATP can be released from the cytosol of damaged cells or …

32 ago. Cells display complex mechanisms to synthesize ATP and to control its cytosolic
level. More recently, extracellular ATP (and/or ADP), at low concentrations, has also been …

… trast with the marked stimulation by PAF of PLD activity in the human U937 promonocytic
cell line (49) and the ability C. El-Moatassim and GRDubyak, unpublished observations. of PAF …

… Duplicate samples (1 ml) were incubated for 10 min at 37 "C prior to addition of the indicated
concentrations of BzATP. After a 15-min incubation at 37 "C, reactions were terminated and …

Extracellular ATP activates two distinct types of P2 purinoreceptor-mediated signaling
pathways in macrophages, 1) the rapid formation of nonselective pores/channels in the plasma …

Exogeneous nucleotides or nucleosides may influence lymphocyte functions such as
proliferation and cytotoxicity. We report that ATP, and to a lesser extent ADP, at concentrations as …

We have previously demonstrated that exogenous ATP can give medullary thymocytes the
calcium message required for the induction of their blastogenesis. In the present study, using …

… do not require the transfer of a phosphate group (El-Moatassim et al., 1987, 1989a, 1989b): …
thymocytes proliferate in response to ATP (El-Moatassim et al., 1987); the ATP 4- opened …

Increased rates of monovalent cation fluxes are implicated in the activation of lymphocytes by
mitogens. Our report shows that amiloride and dimethylamiloride, two inhibitors of the Na + …

… of these compounds for stimulation of the inositol phosphate (IP) accumulation at 37C were
intermediate between their apparent dissociation constants at 2C (K i 2 ) and at 37C (K i 37 ). …