User profiles for CHUNG-KE CHANG
 | Chung-ke ChangAcademia Sinica Verified email at ibms.sinica.edu.tw Cited by 2756 |
Modular organization of SARS coronavirus nucleocapsid protein
C Chang, SC Sue, T Yu, CM Hsieh, CK Tsai… - Journal of biomedical …, 2006 - Springer
The SARS-CoV nucleocapsid (N) protein is a major antigen in severe acute respiratory
syndrome. It binds to the viral RNA genome and forms the ribonucleoprotein core. The SARS-…
syndrome. It binds to the viral RNA genome and forms the ribonucleoprotein core. The SARS-…
The SARS coronavirus nucleocapsid protein–forms and functions
C Chang, MH Hou, CF Chang, CD Hsiao, T Huang - Antiviral research, 2014 - Elsevier
The nucleocapsid phosphoprotein of the severe acute respiratory syndrome coronavirus (SARS-CoV
N protein) packages the viral genome into a helical ribonucleocapsid (RNP) and …
N protein) packages the viral genome into a helical ribonucleocapsid (RNP) and …
Structure of the SARS coronavirus nucleocapsid protein RNA-binding dimerization domain suggests a mechanism for helical packaging of viral RNA
Coronavirus nucleocapsid proteins are basic proteins that encapsulate viral genomic RNA
to form part of the virus structure. The nucleocapsid protein of SARS-CoV is highly antigenic …
to form part of the virus structure. The nucleocapsid protein of SARS-CoV is highly antigenic …
Assembly of severe acute respiratory syndrome coronavirus RNA packaging signal into virus-like particles is nucleocapsid dependent
…, IY Chen, CK Chang, TH Huang, MF Chang - Journal of …, 2005 - Am Soc Microbiol
The severe acute respiratory syndrome coronavirus (SARS-CoV) was recently identified as
the etiology of SARS. The virus particle consists of four structural proteins: spike (S), small …
the etiology of SARS. The virus particle consists of four structural proteins: spike (S), small …
Multiple nucleic acid binding sites and intrinsic disorder of severe acute respiratory syndrome coronavirus nucleocapsid protein: implications for ribonucleocapsid …
CK Chang, YL Hsu, YH Chang, FA Chao… - Journal of …, 2009 - Am Soc Microbiol
The nucleocapsid protein (N) of the severe acute respiratory syndrome coronavirus (SARS-CoV)
packages the viral genomic RNA and is crucial for viability. However, the RNA-binding …
packages the viral genomic RNA and is crucial for viability. However, the RNA-binding …
[HTML][HTML] Transient oligomerization of the SARS-CoV N protein–implication for virus ribonucleoprotein packaging
The nucleocapsid (N) phosphoprotein of the severe acute respiratory syndrome coronavirus
(SARS-CoV) packages the viral genome into a helical ribonucleocapsid and plays a …
(SARS-CoV) packages the viral genome into a helical ribonucleocapsid and plays a …
The N-terminus of TDP-43 promotes its oligomerization and enhances DNA binding affinity
TDP-43 is a DNA/RNA-binding protein associated with different neurodegenerative diseases
such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-…
such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-…
Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein
C Chang, SC Lo, YS Wang, MH Hou - Drug discovery today, 2016 - Elsevier
Highlights • Coronavirus nucleocapsid proteins are appealing drug targets against
coronavirus-induced diseases. • A variety of compounds targeting the coronavirus nucleocapsid …
coronavirus-induced diseases. • A variety of compounds targeting the coronavirus nucleocapsid …
Structure-based stabilization of non-native protein–protein interactions of coronavirus nucleocapsid proteins in antiviral drug design
Structure-based stabilization of protein–protein interactions (PPIs) is a promising strategy
for drug discovery. However, this approach has mainly focused on the stabilization of native …
for drug discovery. However, this approach has mainly focused on the stabilization of native …
Solution structure of the c-terminal dimerization domain of SARS coronavirus nucleocapsid protein solved by the SAIL-NMR method
The C-terminal domain (CTD) of the severe acute respiratory syndrome coronavirus (SARS-CoV)
nucleocapsid protein (NP) contains a potential RNA-binding region in its N-terminal …
nucleocapsid protein (NP) contains a potential RNA-binding region in its N-terminal …