Most enzymatic transformations have a synthetic counterpart. Often though, the mechanisms
by which natural and synthetic catalysts operate differ markedly. The catalytic asymmetric …

Zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs)
comprise a powerful class of tools that are redefining the boundaries of biological research. …

… He then joined the laboratories of Carlos F. Barbas, III, for two years as a postdoctoral
fellow at The Scripps Research Institute, studying organocatalysis. He is currently a process …

Direct asymmetric catalytic aldol reactions have been successfully performed using aldehydes
and unmodified ketones together with commercially available chiral cyclic secondary …

The creation of enzymes capable of catalyzing any desired chemical reaction is a grand
challenge for computational protein design. Using new algorithms that rely on hashing …

The ability of antibodies to neutralize diverse primary isolates of human immunodeficiency
virus-type 1 in vitro has been questioned, with implications for the likely efficacy of vaccines. A …

ErbB2 is a receptor tyrosine kinase whose activity in normal cells depends on dimerization
with another ligand-binding ErbB receptor. In contrast, amplification of c-erbB2 in tumors …

We have developed direct asymmetric cross-aldol reactions that can be performed in water
without addition of organic solvents. A bifunctional catalyst with a long hydrophobic alkyl …

To create a universal system for the control of gene expression, we have studied methods
for the construction of novel polydactyl zinc finger proteins that recognize extended DNA …

Spirooxindoles have become a privileged skeleton given their broad and promising activities
in various therapeutic areas. The strategies and catalyst systems described here highlight …