Synthesis and biological evaluation of indole-2-carboxamides bearing photoactivatable functionalities as novel allosteric modulators for the cannabinoid CB1 receptor
CJ Qiao, HI Ali, KH Ahn, S Kolluru, DA Kendall… - European journal of …, 2016 - Elsevier
5-Chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide (ORG27569, 1)
is a prototypical allosteric modulator for the cannabinoid CB1 receptor. Based on this indole-2…
is a prototypical allosteric modulator for the cannabinoid CB1 receptor. Based on this indole-2…
Pyrimidinyl Biphenylureas Act as Allosteric Modulators to Activate Cannabinoid Receptor 1 and Initiate β-Arrestin–Dependent Responses
Cannabinoid receptor 1 (CB 1 ) is a G-protein–coupled receptor that is abundant in the
central nervous system. It binds several compounds in its orthosteric site, including the …
central nervous system. It binds several compounds in its orthosteric site, including the …
[HTML][HTML] Asymmetric synthesis and absolute configuration assignment of a new type of bedaquiline analogue
CJ Qiao, XK Wang, F Xie, W Zhong, S Li - Molecules, 2015 - mdpi.com
Bedaquiline is the first FDA-approved new chemical entity to fight multidrug-resistant
tuberculosis in the last forty years. Our group replaced the quinoline ring with a naphthalene ring, …
tuberculosis in the last forty years. Our group replaced the quinoline ring with a naphthalene ring, …
Dam impacts on the Changjiang (Yangtze) River sediment discharge to the sea: The past 55 years and after the Three Gorges Dam
… responsible for the change in Changjiang sediment discharge recorded by looking at
hydrologic data from key gauging stations along the Changjiang and its main tributaries between …
hydrologic data from key gauging stations along the Changjiang and its main tributaries between …
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations
Esophageal squamous-cell carcinoma (ESCC) is one of the most prevalent cancers worldwide
and occurs at a relatively high frequency in China. To identify genetic susceptibility loci …
and occurs at a relatively high frequency in China. To identify genetic susceptibility loci …
Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions
We conducted a genome-wide association study (GWAS) and a genome-wide gene-environment
interaction analysis of esophageal squamous-cell carcinoma (ESCC) in 2,031 affected …
interaction analysis of esophageal squamous-cell carcinoma (ESCC) in 2,031 affected …
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations
…, SM Dawsey, L Liao, MP Lee, T Ding, YL Qiao… - Nature …, 2014 - nature.com
We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) 1
, 2 , 3 of esophageal squamous cell carcinoma (ESCC) in individuals of Chinese ancestry (…
, 2 , 3 of esophageal squamous cell carcinoma (ESCC) in individuals of Chinese ancestry (…
Experimental study on fire behaviors of RC restrained beams during heating and cooling phases
W Bo, Q Chang-jiang - 工程力学, 2011 - engineeringmechanics.cn
In order to investigate the fire behaviors of reinforced concrete (RC) restrained beams during
heating and cooling phases, eight restrained RC beams were tested in fire with a cooling …
heating and cooling phases, eight restrained RC beams were tested in fire with a cooling …
[HTML][HTML] Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls
…, L Jiang, BKW Ng, B Shi, W Zhang, J Qiao… - Nature …, 2015 - nature.com
Adolescent idiopathic scoliosis (AIS) is a structural deformity of the spine affecting millions
of children. As a complex disease, the genetic aetiology of AIS remains obscure. Here we …
of children. As a complex disease, the genetic aetiology of AIS remains obscure. Here we …
Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma
We conducted a genome-wide scan of SNPs to identify variants associated with length of
survival in 1,331 individuals with esophageal squamous-cell carcinoma (ESCC), with …
survival in 1,331 individuals with esophageal squamous-cell carcinoma (ESCC), with …