Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study

…, CM Chour, S Prom, CA Lanteri… - The Lancet Infectious …, 2015 - thelancet.com
Background Dihydroartemisinin-piperaquine has been adopted as first-line artemisinin
combination therapy (ACT) for multidrug-resistant Plasmodium falciparum malaria in Cambodia …

Association of a Novel Mutation in the Plasmodium falciparum Chloroquine Resistance Transporter With Decreased Piperaquine Sensitivity

…, R Huy, MD Spring, CA Lanteri… - The Journal of …, 2017 - academic.oup.com
Background Amplified copy number in the plasmepsin II/III genes within Plasmodium
falciparum has been associated with decreased sensitivity to piperaquine. To examine this …

Durability of SARS-CoV-2–specific T-cell responses at 12 months postinfection

…, CC Broder, A Ganesan, CA Lanteri… - The Journal of …, 2021 - academic.oup.com
Background Characterizing the longevity and quality of cellular immune responses to severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enhances understanding of …

Ex Vivo Drug Susceptibility Testing and Molecular Profiling of Clinical Plasmodium falciparum Isolates from Cambodia from 2008 to 2013 Suggest Emerging …

…, P Teja-Isavadharm, C Lon, CA Lanteri - Antimicrobial agents …, 2015 - Am Soc Microbiol
Cambodia's first-line artemisinin combination therapy, dihydroartemisinin-piperaquine (DHA-PPQ),
is no longer sufficiently curative against multidrug-resistant Plasmodium falciparum …

The Mitochondrion Is a Site of Trypanocidal Action of the Aromatic Diamidine DB75 in Bloodstream Forms of Trypanosoma brucei

CA Lanteri, RR Tidwell… - Antimicrobial agents and …, 2008 - Am Soc Microbiol
Human African trypanosomiasis (HAT) is a fatal tropical disease caused by infection with
protozoans of the species Trypanosoma brucei gambiense and T. b. rhodesiense. An oral …

Design of anti-parasitic and anti-fungal hydroxy-naphthoquinones that are less susceptible to drug resistance

LM Hughes, CA Lanteri, MT O'Neil, JD Johnson… - Molecular and …, 2011 - Elsevier
Atovaquone is a hydroxy-naphthoquinone that is used to treat parasitic and fungal infections
including Plasmodium falciparum (malaria), Pneumocystis jivorecii (pneumonia) and …

New chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeleton

I Opsenica, D Opsenica, CA Lanteri… - Journal of medicinal …, 2008 - ACS Publications
The synthesis of the chimeric molecules consisting of two pharmacophores, tetraoxane and
7-chloro-4-aminoquinoline, is reported. The tetraoxanes 2, 4, and 8 show relatively potent in …

Selective sweep suggests transcriptional regulation may underlie Plasmodium vivax resilience to malaria control measures in Cambodia

…, EJ Barnett, C Lon, CA Lanteri… - Proceedings of the …, 2016 - National Acad Sciences
Cambodia, in which both Plasmodium vivax and Plasmodium falciparum are endemic, has
been the focus of numerous malaria-control interventions, resulting in a marked decline in …

Partner-Drug Resistance and Population Substructuring of Artemisinin-Resistant Plasmodium falciparum in Cambodia

…, SR Meshnick, MD Spring, CA Lanteri… - Genome biology and …, 2017 - academic.oup.com
Plasmodium falciparum in western Cambodia has developed resistance to artemisinin and
its partner drugs, causing frequent treatment failure. Understanding this evolution can inform …

Report of the national institutes of health SARS-CoV-2 antiviral therapeutics summit

…, FG Hayden, DJ Hazuda, CA Lanteri… - The Journal of …, 2021 - academic.oup.com
The NIH Virtual SARS-CoV-2 Antiviral Summit, held on 6 November 2020, was organized to
provide an overview on the status and challenges in developing antiviral therapeutics for …