The availability of high-affinity agonists for peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)
has led to significant advances in our understanding of the functional role of PPARβ/…

The RAS signaling pathway is constitutively activated in psoriatic keratinocytes. We expressed
activated H-RAS V12G in suprabasal keratinocytes of adult mice and observed rapid …

Perfluorobutryate (PFBA) is a short chain perfluoroalkyl carboxylate that is structurally
similar to perfluorooctanoate. Administration of PFBA can cause peroxisome proliferation, …

Recent work indicates that PPARα is required for perfluorooctanoic acid (PFOA)-induced
postnatal lethality resulting from prenatal exposure. The present study tested the hypothesis …

Background Periplakin (PPL) is a rod-shaped cytolinker protein thought to connect cellular
adhesion junctional complexes to cytoskeletal filaments. PPL serves as a structural …

Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular
heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights …

Perfluorobutryate (PFBA) is a short chain perfluoroalkyl carboxylate that is structurally
similar to perfluorooctanoate. Administration of PFBA can cause peroxisome proliferation, …

In addition to its function as a cyclin-dependent kinase (cdk) inhibitor, p21 waf1 fulfills
additional roles involved in DNA replication and transcriptional regulation that could also …

In order to reduce the energy load, understanding the overall architectural design features
and optimizing building orientation are important. They are guided by natural elements like …

The response of BRAF-mutant melanoma patients to BRAF inhibitors is dramatically impaired
by secondary resistances and rapid relapse. So far, the molecular mechanisms driving …