Cannabidiol: State of the art and new challenges for therapeutic applications
…, G Faggiana, MC Proto, D Fiore, C Laezza… - Pharmacology & …, 2017 - Elsevier
Over the past years, several lines of evidence support a therapeutic potential of Cannabis
derivatives and in particular phytocannabinoids. Δ 9 -THC and cannabidiol (CBD) are the most …
derivatives and in particular phytocannabinoids. Δ 9 -THC and cannabidiol (CBD) are the most …
Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
Δ 9 -Tetrahydrocannabinol (THC) exhibits antitumor effects on various cancer cell types, but
its use in chemotherapy is limited by its psychotropic activity. We investigated the antitumor …
its use in chemotherapy is limited by its psychotropic activity. We investigated the antitumor …
Pharmacological actions of statins: a critical appraisal in the management of cancer
Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently, a …
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently, a …
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
…, A Palmisano, T Bisogno, C Laezza… - Proceedings of the …, 1998 - National Acad Sciences
Anandamide was the first brain metabolite shown to act as a ligand of “central” CB1 cannabinoid
receptors. Here we report that the endogenous cannabinoid potently and selectively …
receptors. Here we report that the endogenous cannabinoid potently and selectively …
[HTML][HTML] Cannabinoids: therapeutic use in clinical practice
Medical case reports suggest that cannabinoids extracted from Cannabis sativa have therapeutic
effects; however, the therapeutic employment is limited due to the psychotropic effect of …
effects; however, the therapeutic employment is limited due to the psychotropic effect of …
Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell …
Anandamide and 2-arachidonoylglycerol (2-AG), two endogenous ligands of the CB1 and
CB2 cannabinoid receptor subtypes, inhibit the proliferation of PRL-responsive human breast …
CB2 cannabinoid receptor subtypes, inhibit the proliferation of PRL-responsive human breast …
The endocannabinoid signaling system in cancer
S Pisanti, P Picardi, A D'Alessandro, C Laezza… - Trends in …, 2013 - cell.com
Changes in lipid metabolism are intimately related to cancer. Several classes of bioactive
lipids play roles in the regulation of signaling pathways involved in neoplastic transformation …
lipids play roles in the regulation of signaling pathways involved in neoplastic transformation …
Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis
G Portella, C Laezza, P Laccetti… - The FASEB …, 2003 - Wiley Online Library
Stimulation of cannabinoid CB 1 receptors by 2‐methyl‐arachidonyl‐2′‐fluoro‐ethylamide
(Met‐F‐AEA) inhibits the growth of a rat thyroid cancer cell‐derived tumor in athymic mice by …
(Met‐F‐AEA) inhibits the growth of a rat thyroid cancer cell‐derived tumor in athymic mice by …
Cannabinoids and cancer: pros and cons of an antitumour strategy
In the last two decades, research has dramatically increased the knowledge of cannabinoids
biology and pharmacology. In mammals, compounds with properties similar to active …
biology and pharmacology. In mammals, compounds with properties similar to active …
Anandamide inhibits adhesion and migration of breast cancer cells
C Grimaldi, S Pisanti, C Laezza, AM Malfitano… - Experimental cell …, 2006 - Elsevier
The endocannabinoid system regulates cell proliferation in human breast cancer cells. We
reasoned that stimulation of cannabinoid CB 1 receptors could induce a non-invasive …
reasoned that stimulation of cannabinoid CB 1 receptors could induce a non-invasive …