Adenosine is an immunosuppressive factor that limits anti-tumor immunity through the
suppression of multiple immune subsets including T cells via activation of the adenosine A 2A …

The immune system plays a major role in the surveillance and control of malignant cells,
with the presence of tumor infiltrating lymphocytes (TILs) correlating with better patient …

Posttreatment recurrence of colorectal cancer, the third most lethal cancer worldwide, is often
driven by a subpopulation of cancer stem cells (CSC). The tight junction (TJ) protein claudin…

Surgery remains the curative treatment modality for colorectal cancer in all stages, including
stage IV with resectable liver metastasis. There is emerging evidence that the stress …

Objective Although counting of circulating tumour cells (CTC) has attracted a broad interest
as potential markers of tumour progression and treatment response, the lack of functional …

Herein, we report the discovery of a series of JAK1-selective kinase inhibitors with high
potency and excellent JAK family subtype selectivity. A fragment screening hit 1 with a …

Since its discovery in 1992, mGluR5 has attracted significant attention and been linked to
several neurological and psychiatric diseases. Ligand development was initially focused on …

Purpose Adenosine is a multifaceted regulator of tumor progression. It modulates immune cell
activity as well as acting directly on tumor cells. The A 2b adenosine receptor (A 2b -AR) is …

Tralokinumab, a fully human mAb specifically targeting the IL-13 cytokine, has demonstrated
clinical efficacy and safety in patients with moderate-to-severe atopic dermatitis. …

Metabotropic glutamate receptor subtype 5 (mGluR5) is a potential drug target in neurological
and psychiatric disorders, and subtype-selective allosteric modulators have attracted …